| protein
| fragile X mental retardation, autosomal homolog 1, FXR1 and fragile X mental retardation, autosomal homolog 2, FXR2 ( |
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nuclear FMRP interacting protein, NUFIP ( |
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Y box-binding protein 1, YB1 ( |
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ubiquitin-conjugating 9, UBC9 ( |
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with RANBP9(functional role of RanBP9 binding is modulation of the RNA-binding properties of FMR1) |
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associated with BCYRN1 to regulates the translation of specific mRNA at synapses |
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with MBP (target for FMR1 during oligodendrocyte development) |
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post-translationally methylated, primarily on its arginine-glycine-glycine box, by HRMT1L2, for modifying FMR1 function (suggesting that methylation occurs to limit or modulate RNA binding by FMR1) |
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interaction between FMR1/CYFIP1 and EIF4E is increased and possibly stabilized by the presence of target mRNAs |
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FMR1–TDRD3 interaction (mutation impairing this interaction might contribute to the pathogenesis of Fragile X syndrome) |
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cytoplasmic FMR1 interacting protein 1, CYFIP1 and cytoplasmic FMR1 interacting protein 2, CYFIP2 ( |
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82-kD FMRP Interacting Protein, 82-FIP ( |
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multi-domain Ran-binding protein in the microtubule-organising centre, RanBPM ( |
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endogenous ZBTB14 acts as a repressor of the human FMR1 gene |
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molecular link between GRM1 and FMR1 in the anterior cingulate cortex (ACC), a key region involved in high brain cognitive and executive functions |
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interacting with MAP1B (MAP1B RNA forms an intramolecular G quadruplex structure, which is bound with high affinity and specificity by the FMR1 RGG box) |
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binds intramolecular G-quadruplex and kissing complex RNA (kcRNA) ligands via the RGG box and KH2 domain |
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interacting with SHANK1 (represses translation of SHANK1 transcripts in neurons via an interaction with its 3 prime UTR, but translation block is abolished upon the activation of GRMs and deregulated postsynaptic synthesis of SHANK1 may significantly contribute to the aberrant dendritic spine morphology caused by the absence of FMR1) |
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binds to the C terminus of KCNT1 sodium-activated potassium channel to activate the channel |
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interaction of KCNT1 channels with FMR1 serves to regulate the proposed functions of FMR1 in mRNA trafficking and translation |
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targets ERK1 and the MTOR inhibitors PTEN, NF1, and TSC2, proteins closely linked to autism, supporting the possibility that pharmacologic agents acting on the MTOR and ERK pathways may be clinically relevant for FRAXA and autism |
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FMR1 regulates translation of NOS1 in the developing human neocortex, and alterations in FMR1 posttranscriptional regulation of NOS1 in developing neocortical circuits may contribute to cognitive dysfunction in FRAXA |
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TARDBP is physically associated with fragile X mental retardation protein (FMR1) and Staufen (STAU1) to form a functional complex |
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TARDBP/FMR1/STAU1 specifically binds to the 3prime-UTR of SIRT1 mRNA ( |
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MEF2A and FMR1 cooperatively regulate the expression of PCDH10 |
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protein-protein interaction of RALY with EIF4A3, FMR1, and HNRNPC |
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CTCF has a complex role in regulating FMR1 expression, probably through the organization of chromatin loops between sense/antisense transcriptional regulatory regions |
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PKP4 is an important and novel FMR1 target, strongly suggesting that impaired actin cytoskeletal functions mediated by an excess of PKP4 are key aspects underlying the fragile X syndrome |
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MYO5A and kinesin play likely key roles in the assembly and subsequent transport of FMR1 granules along microtubules to the periphery of the cell |
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STUB1 ubiquitinated FMR1 for proteasomal degradation in a molecular chaperone-independent manner |
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FMR1 associates with the RNA helicase MOV10, also associated with the microRNA pathway, in an RNA-dependent manner and facilitates MOV10 association with RNAs in brain and cells, suggesting a cooperative interaction |
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MKNK1, MKNK2 increased the binding of EIF4E to the cytoplasmic FMR1-interacting protein 1 (CYFIP1), which binds the fragile-X mental retardation protein, FMR1, a translational repressor |
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potential role for GABBR1 in FMR1 regulation and potential interest of GABAB receptor signaling in FRAXA improvement |
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FMR1 and FXR2 additively promote the maturation of new neurons by regulating a common target, the AMPA receptor GRIA1, but via distinct mechanisms |
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coordinated regulation of DLG4 mRNA by FMR1 and FXR2 that ultimately affects its fine-tuning during synaptic activity. |
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functional/physical partnership between FMR1 and TARDBP that mechanistically links several neurodevelopmental disorders and neurodegenerative diseases |
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FMR1 regulation of muscle stem cells (MuSCs) activity occurs in part by the capacity of FMR1 to directly bind MYF5 transcripts and impact rates of MYF5 deadenylation |
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FMR1 interacts with the 3'UTR of the NRGN mRNA and is required for activity-dependent translation of NRGN in the synaptic compartment and contextual memory formation |
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FMR1 regulates the stability of its m6A-marked mRNA targets through YTHDF2, which could potentially contribute to the molecular pathogenesis of Fragile X syndrome (FXS) |
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FMR1 is required for translation downstream of GRIN1 stimulation and MOV10 is the key specificity factor in this process |
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DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation |
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MOV10-FMR1-AGO2 complex regulates DICER1 expression, revealing a novel mechanism for regulation of miRNA production required for normal neuronal morphology |
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MOV10 functionally associates with FMR1 |
