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FLASH GENE

Symbol

ZNF41

contributors: mct - updated : 09-10-2017

HGNC name	zinc finger protein 41
HGNC id	13107

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	38.98 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	see ZNF157

RNA

TRANSCRIPTS	type	messenger

text	several transcripts

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007130 5 - 5359 NP_009061 89 779 - 1999 10449920 NM_153380 5 splicing 5232 NP_700359 89 779 - 1999 10449920 different 5'UTR NM_001324139 4 - 4666 NP_001311068 - 693 - 1999 10449920 NM_001324141 4 - 4695 NP_001311070 - 693 - 1999 10449920 NM_001324140 5 - 4956 NP_001311069 89 779 - 1999 10449920 NM_001324147 5 - 5017 NP_001311076 89 779 - 1999 10449920 NM_001324144 5 - 5046 NP_001311073 - 779 - 1999 10449920 NM_001324150 6 - 5144 NP_001311079 89 779 - 1999 10449920 NM_001324152 6 - 5132 NP_001311081 - 693 - 1999 10449920 NM_00132414 4 - 4711 NP_001311074 - 693 - 1999 10449920 NM_001324142 5 - 4972 NP_001311071 - 781 - 1999 10449920 NM_001324148 5 - 5062 NP_001311077 - 781 - 1999 10449920 NM_001324149 4 - 4735 NP_001311078 - 693 - 1999 10449920 NM_001324153 5 - 4996 NP_001311082 - 789 - 1999 10449920 NM_001324151 5 - 5086 NP_001311080 - 789 - 1999 10449920 NM_001324143 4 - 5008 NP_001311072 - 693 - 1999 10449920 NM_001324155 4 - 4907 NP_001311084 - 621 - 1999 10449920 NM_001324156 4 - 4688 NP_001311085 - 745 - 1999 10449920 NM_001324154 4 - 4883 NP_001311083 - 813 - 1999 10449920 NM_001324157 4 - 4673 NP_001311086 - 743 - 1999 10449920

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain         Skeleton axial skull face maxilla   Visual eye lens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a KRAB/FBP (Kruppel associated box) at the N terminus
	a potent transcription repression motif and 18 zinc finger motifs, C2H2 type, Krüppel-like, tandemly arranged at the C terminus

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

zinc finger protein family, C2H2 type, Krüppel-like,KRAB subfamily

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in gene-specific transcriptional repression
	may be playing a critical role for cognitive development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRX89

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS