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FLASH GENE
Symbol RBM10 contributors: mct/npt - updated : 20-04-2022
HGNC name RNA binding motif protein 10
HGNC id 9896
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two tandem RNP motifs
  • a repeat of five octamers and an emphipathic alpha-helix
  • a zinc finger motif
  • a G patch
  • two RNA recognition motif (RRM) domains
    • HOMOLOGY
    interspecies ortholog to murine Rbm10
    homolog to Drosophila CG4896
    intraspecies paralog to RBM5
    Homologene
    FAMILY
  • RBM proteins family of apoptosis modulators
    • CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner (Inoue 2008)
    basic FUNCTION
  • with CASP3, involved in the last steps of the apoptotic cascade in breast cancer (Martín-Garabato 2008)
  • possesses multiple nucleolar and cellular functions in vascular smooth muscle cells (VSMC)(Mueller 2009)
  • regulates AT1 receptor gene (AGTR1) expression via transcriptional and posttranscriptional mechanisms (Mueller 2009)
  • is an important regulator of alternative splicing
  • nuclear RNA-binding protein with domains characteristic of RNA processing proteins
  • RBM10 promotes exon skipping of FAS pre-mRNA as well as selection of an internal 5'-splice site in BCLX pre-mRNA
  • RBM10 can function as an apoptosis modulator and cytokine expression regulator
  • is a regulator of alternative splicing in apoptosis and inflammation
  • anti-hypertrophy mechanism mediated by RBM10 in the heart that is directly linked to heart failure (HF)
  • acts as a tumor suppressor in osteosarcoma
  • nuclear RNA-binding protein (RBP) that regulates the alternative splicing of primary transcripts
  • is involved in alternative splicing and modifies mRNA post-transcriptionally
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to RNA homopolymers with a preference for G and U polyribonucleotides
    small molecule metal binding,
  • Zn2+
    • protein
  • autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay
  • can induce apoptosis and inhibit cancer cell proliferation by activating TP53
  • inhibits cancer cell proliferation and induces apoptosis in part by blocking the MDM2-TP53 feedback loop
  • RBM10 role in TP53-dependent cancer prevention
  • regulates human TERT gene splicing and inhibits pancreatic cancer progression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TARP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    leads to increased apoptosis in vascular smooth muscle cells (VSMC) and decreases VSMC proliferation (Mueller 2009)
    tumoral germinal mutation      
    contribute to lung adenocarcinoma (LUAD) pathogenesis, at least in large part, by deregulating splicing
    constitutional     --low  
    during cardiac hypertrophy (CH) and heart failure (HF)
    tumoral     --over  
    induced osteosarcoma cell apoptosis via the inhibition of BCL2, the activation of CASP3, and the transcription and production of TNF 0)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS