Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

RGN

contributors: mct - updated : 13-11-2024

HGNC name	regucalcin (senescence marker protein-30)
HGNC id	9989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   may contribute to the worsening of glucose tolerance that occurs in normal aging constitutional     --low   in nonalcoholic fatty liver disease tumoral     --low   in breast and prostate cancer cases and the regulation of its expression by sex steroid hormones suggest that it may be associated with development and progression of these tumors ( constitutional     --over   cardiac-specific overexpression of RGN inhibited AGT -induced cardiac adverse remodeling

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	reliable biomarker in various disorders of liver, kidney, brain and ocular
	utility of RGN signaling as biomarkers for predicting recurrence of prostate carcinoma
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   therapeutic target to prevent cardiac hypertrophy and remodeling due to hypertension cancer reproductive breast extracellular RGN may play a role as a suppressor in the growth of mammary epithelial cells with TP53 loss, providing a novel strategy for cancer

ANIMAL & CELL MODELS