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FLASH GENE

Symbol

RGN

contributors: mct - updated : 13-11-2024

HGNC name	regucalcin (senescence marker protein-30)
HGNC id	9989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Digestive liver       predominantly Homo sapiens Reproductive female system breast       Homo sapiens   male system prostate       Homo sapiens   male system testis       Homo sapiens Urinary kidney       predominantly

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte Reproductive Leydig cell Homo sapiens Reproductive Sertoli cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus regucalcin
	ortholog to murine Rgn
	homolog to Drosophila regucalcin
	homolog to C.elegans C08F11.5

intraspecies

homolog to senescence marker protein 30

Homologene

FAMILY

SMP-30/CGR1 family

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	playing an important role in calcium homeostasis
	playing a role in aging and in the regulation of the enzymatic activity in the liver
	has protective effects against age-associated oxidative stress in brain and lungs
	cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical warfare nerve agents
	glucolactonase, which is a key enzyme for l-ascorbic acid (vitamin C) biosynthesis
	has a suppressive effect on calcium signaling from the cytoplasm to the nucleus in the proliferative cells
	plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function
	calcium (Ca(2)(+))-binding protein which regulates intracellular Ca(2)(+) homeostasis by modulating the activity of enzymes regulating Ca(2)(+) concentration and enhancing Ca(2)(+)-pumping activity
	may have a role in male reproductive function, particularly in the control of spermatogenesis
	plays a role in Ca(2+) homeostasis by modulating a number of Ca(2+)-dependent proteins
	also plays a cyto-protective role and its decrease is linked to age-related diseases and cell death
	having a cardio-protective role with anti-oxidative and anti-aging effects
	exogenous RGN may play a pivotal role in the regulation of bone homeostasis as a suppressor in osteoblastogenesis and an enhancer in osteoclastogenesis, suggesting its role as a cytokine
	play a multifunctional role in cell regulation, such as maintainance of intracellular Ca2+ homeostasis and suppression of signal transduction, protein synthesis, nuclear function, cell proliferation and apoptosis in various types of cells and tissues
	RGN may be a key molecule in heart muscle cell regulation through Ca2+ signaling, and may also play a pathophysiological role in heart failure
	protective role of RGN in the carcinogenesis of mammary gland
	role of RGN suppressing cell proliferation associated with the regulation of expression of oncogenes and tumor suppressor genes
	acts as a Ca2+ regulatory protein and controls various cellular functions in liver and other organs
	has multiple functions as an inhibitor of various cellular signaling pathways that regulate cell activity
	plays an important role in the development of several cancers by controlling cell growth
	regucalcin may act as a potential suppressor of various types of human cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text

calcium

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	prevented cardiac hypertrophy and diastolic dysfunction by AGT
	interaction between UPK1A and RGN or PSMB1 could be required for spermatogenesis

cell & other

REGULATION

repressed by

aging (age-associated down-regulation)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   may contribute to the worsening of glucose tolerance that occurs in normal aging constitutional     --low   in nonalcoholic fatty liver disease tumoral     --low   in breast and prostate cancer cases and the regulation of its expression by sex steroid hormones suggest that it may be associated with development and progression of these tumors ( constitutional     --over   cardiac-specific overexpression of RGN inhibited AGT -induced cardiac adverse remodeling

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	reliable biomarker in various disorders of liver, kidney, brain and ocular
	utility of RGN signaling as biomarkers for predicting recurrence of prostate carcinoma
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   therapeutic target to prevent cardiac hypertrophy and remodeling due to hypertension cancer reproductive breast extracellular RGN may play a role as a suppressor in the growth of mammary epithelial cells with TP53 loss, providing a novel strategy for cancer

ANIMAL & CELL MODELS