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FLASH GENE

Symbol

ZFX

contributors: mct - updated : 21-05-2024

HGNC name	zinc finger protein, X-linked
HGNC id	12869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRXS37

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in laryngeal squamous cell carcinoma, associated with its progression tumoral     --low   in renal cell carcinoma (RCC) tissues tumoral somatic mutation       in sporadic parathyroid adenomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	ZFX could be considered as a predictor for prognosis of renal cell carcinoma (RCC) patients
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma lentivirus-mediated RNAi targeting of ZFX may serve as a promising strategy for glioma therapy

ANIMAL & CELL MODELS

	Zfx-deficient pluripotent embryonic SC (ESC) and hematopoietic SC (HSC)showed increased apoptosis and SC-specific upregulation of stress-inducible genes (
	male and female Zfx-/- mice displayed impaired embryonic growth and reduced adult body size and germ cell number