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FLASH GENE
Symbol ZFX contributors: mct - updated : 21-05-2024
HGNC name zinc finger protein, X-linked
HGNC id 12869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal acidic transactivation domain
  • a putative nuclear localization signal (NLS)
  • 13 zinc fingers in the C terminal region, of which the final three are necessary and sufficient for recruitment to promoter region
    • HOMOLOGY
    interspecies homolog to rattus LOC367832
    homolog to murine Zfx
    Homologene
    FAMILY
  • krueppel c2h2-type zinc-finger protein family
  • zfx/zfy subfamily
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • shared transcriptional regulator of pluripotent embryonic stem cells (ESC) and hematopoietic SC (HSC),suggesting a common genetic basis of self-renewal in embryonic and adult stem cells
  • regulator of hematopoietic stem cell maintenance, in B-cell development and homeostasis
  • restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis
  • ZFX acts as a molecular rheostat regulating the balance between self-renewal and differentiation in Embryonic stem cells (ESCs)
  • functions as an important regulator of self-renewal in multiple stem cell types, as well as a sex determinant of mammals
  • acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters
  • is an important regulator of peripheral T cell maintenance and expansion
  • ZFX likely enhances elongation at target promoters by recruiting H4 acetylation complexes and reducing pausing
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • ZFX is an upstream factor regulating SET gene expression.
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRXS37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in laryngeal squamous cell carcinoma, associated with its progression
    tumoral     --low  
    in renal cell carcinoma (RCC) tissues
    tumoral somatic mutation      
    in sporadic parathyroid adenomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ZFX could be considered as a predictor for prognosis of renal cell carcinoma (RCC) patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    lentivirus-mediated RNAi targeting of ZFX may serve as a promising strategy for glioma therapy
    ANIMAL & CELL MODELS
  • Zfx-deficient pluripotent embryonic SC (ESC) and hematopoietic SC (HSC)showed increased apoptosis and SC-specific upregulation of stress-inducible genes (
  • male and female Zfx-/- mice displayed impaired embryonic growth and reduced adult body size and germ cell number