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FLASH GENE

Symbol

ZFX

contributors: mct - updated : 21-05-2024

HGNC name	zinc finger protein, X-linked
HGNC id	12869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal acidic transactivation domain
	a putative nuclear localization signal (NLS)
	13 zinc fingers in the C terminal region, of which the final three are necessary and sufficient for recruitment to promoter region

HOMOLOGY

interspecies	homolog to rattus LOC367832
	homolog to murine Zfx

Homologene

FAMILY	krueppel c2h2-type zinc-finger protein family
	zfx/zfy subfamily

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
	intracellular,nucleus,nucleolus

basic FUNCTION	shared transcriptional regulator of pluripotent embryonic stem cells (ESC) and hematopoietic SC (HSC),suggesting a common genetic basis of self-renewal in embryonic and adult stem cells
	regulator of hematopoietic stem cell maintenance, in B-cell development and homeostasis
	restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis
	ZFX acts as a molecular rheostat regulating the balance between self-renewal and differentiation in Embryonic stem cells (ESCs)
	functions as an important regulator of self-renewal in multiple stem cell types, as well as a sex determinant of mammals
	acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters
	is an important regulator of peripheral T cell maintenance and expansion
	ZFX likely enhances elongation at target promoters by recruiting H4 acetylation complexes and reducing pausing

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

ZFX is an upstream factor regulating SET gene expression.

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRXS37

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in laryngeal squamous cell carcinoma, associated with its progression tumoral     --low   in renal cell carcinoma (RCC) tissues tumoral somatic mutation       in sporadic parathyroid adenomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	ZFX could be considered as a predictor for prognosis of renal cell carcinoma (RCC) patients
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma lentivirus-mediated RNAi targeting of ZFX may serve as a promising strategy for glioma therapy

ANIMAL & CELL MODELS

	Zfx-deficient pluripotent embryonic SC (ESC) and hematopoietic SC (HSC)showed increased apoptosis and SC-specific upregulation of stress-inducible genes (
	male and female Zfx-/- mice displayed impaired embryonic growth and reduced adult body size and germ cell number