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FLASH GENE

Symbol

CTSB

contributors: mct/npt/pgu - updated : 04-06-2018

HGNC name	cathepsin B
HGNC id	2527

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

KWE

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in amyotrophic lateral sclerosis tumoral     --over   in malignant anaplastic astrocytomas and glioblastomas constitutional       gain of function in Dementia with Lewy bodies (DLB)

Susceptibility

to osteoarthritis

Variant & Polymorphism other	overexpression of truncated form (lacking exons 2 and 3) in osteoarthritic cartilage

Candidate gene
Marker	might serve as a prognostic and therapeutic marker for lung squamous cell carcinoma
Therapy target
	System Type Disorder Pubmed cancer reproductive breast with its substrate BID were shown to be molecular links between apoptosis and autophagy in breast cancer MCF-7 cells exposed to the cytostatic drug, camptothecin metabolism lysosome   targeting CTSB may be of relevance in the treatment of liver fibrosis in patients with Niemann-Pick disease cancer reproductive uterus potential to provide a new therapeutic target for treating endometrial malignancy miscelleaneous pain   CTSB-specific inhibitors may represent a useful new strategy for treating inflammation-associated pain cancer metastases   therapeutic benefits of its selective inhibition in bone metastasis in breast cancer

ANIMAL & CELL MODELS