| 1 | CBLN1, CTSB
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| Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons.
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| Ibata K, Kono M, Narumi S, Motohashi J, Kakegawa W, Kohda K, Yuzaki M.
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| Neuron. Jun 19;102(6):1184-1198.e10. doi: 10.1016/j.neuron.2019.03.044. Epub 2019 May 6. 2019
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| 2 | CTSB, PSMB8
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| Upregulation of PSMB8 and cathepsins in the human brains of dementia with Lewy bodies. 2018. PMID:
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| Ding Q, Zhu H.
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| Neurosci Lett. Jun 21;678:131-137. doi: 10.1016/j.neulet.2018.05.022 2018
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| 3 | CTSB, KWE
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| Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families.
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| Ngcungcu T, Oti M, Sitek JC, Haukanes BI, Linghu B, Bruccoleri R, Stokowy T, Oakeley EJ, Yang F, Zhu J, Sultan M, Schalkwijk J, van Vlijmen-Willems IMJJ, von der Lippe C, Brunner HG, Ersland KM, Grayson W, Buechmann-Moller S, Sundnes O, Nirmala N, Morgan TM, van Bokhoven H, Steen VM, Hull PR, Szustakowski J, Staedtler F, Zhou H, Fiskerstrand T, Ramsay M.
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| Am J Hum Genet 100(5):737-750. doi: 10.1016/j.ajhg.2017.03.012. Epub 2017 Apr 27.
2017
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| 4 | CTSB, CTSS, CTSZ
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| Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
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| Akkari L, Gocheva V, Quick ML, Kester JC, Spencer AK, Garfall AL, Bowman RL, Joyce JA.
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| Genes Dev 30(2):220-32. doi: 10.1101/gad.270439.115.
2016
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| 5 | CTSB, CTSL
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| Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
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| McGlinchey RP, Lee JC.
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| Proc Natl Acad Sci U S A 112(30):9322-7. doi: 10.1073/pnas.1500937112. Epub 2015 Jul 13.
2015
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| 6 | APP, CTSB
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| Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.
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| Cecarini V, Bonfili L, Cuccioloni M, Mozzicafreddo M, Rossi G, Keller JN, Angeletti M, Eleuteri AM.
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| Biochim Biophys Acta 1842(2):127-34. doi: 10.1016/j.bbadis.2013.11.002. Epub 2013 Nov 8.
2014
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| 7 | CTSB, CTSD, SNCA
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| Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.
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| Crabtree D, Dodson M, Ouyang X, Boyer-Guittaut M, Liang Q, Ballestas ME, Fineberg N, Zhang J.
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| J Neurochem 128(6):950-61. doi: 10.1111/jnc.12497. Epub 2013 Nov 13.
2014
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| 8 | CTSB
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| Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma.
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| Gong F, Peng X, Luo C, Shen G, Zhao C, Zou L, Li L, Sang Y, Zhao Y, Zhao X.
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| Mol Cancer 12(1):125. doi: 10.1186/1476-4598-12-125.
2013
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| 9 | ATG7, CTSB, NLRP3
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| Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line.
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| Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, Zhu J, Chen L, Zhu F, Li C, Yang S.
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| J Biol Chem 288(42):30094-104. doi: 10.1074/jbc.M113.494286. Epub 2013 Aug 28.
2013
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| 10 | CTSB
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| Silencing of Cathepsin B suppresses the proliferation and invasion of endometrial cancer.
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| Bao W, Fan Q, Luo X, Cheng WW, Wang YD, Li ZN, Chen XL, Wu D.
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| Oncol Rep 30(2):723-30. doi: 10.3892/or.2013.2496. Epub 2013 May 27.
2013
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| 11 | CTSB
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| Cathepsin B is a novel gender-dependent determinant of cholesterol absorption from the intestine.
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| Wong WP, Altemus JB, Hester JF, Chan ER, Côté JF, Serre D, Sehayek E.
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| J Lipid Res 54(3):816-22. doi: 10.1194/jlr.M034579. Epub 2012 Dec 17.
2013
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| 12 | CTSB, FDFT1
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| Exclusion of CTSB and FDFT1 as positional and functional candidate genes for keratolytic winter erythema (KWE).
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| Hobbs A, Aron S, Hartshorne S, Hull PR, Ramsay M.
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| J Dermatol Sci 65(1):58-62. Epub 2011 Sep 8.
2012
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| 13 | CTSB, LAMP1, MCOLN1, TRPML
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| Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis.
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| Colletti GA, Miedel MT, Quinn J, Andharia N, Weisz OA, Kiselyov K.
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| J Biol Chem 287(11):8082-91. doi: 10.1074/jbc.M111.285536. Epub 2012 Jan 18. 2012
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| 14 | CTSB
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| Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease.
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| Moles A, Tarrats N, Fernández-Checa JC, Marí M.
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| J Biol Chem 287(2):1178-88. doi: 10.1074/jbc.M111.272393. Epub 2011 Nov 18.
2012
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| 15 | CTSB
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| Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
|
| Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, Nakanishi H.
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| J Neurosci 32(33):11330-42.
2012
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| 16 | CTSB
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| Cathepsin B controls the persistence of memory CD8+ T lymphocytes.
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| Byrne SM, Aucher A, Alyahya S, Elder M, Olson ST, Davis DM, Ashton-Rickardt PG.
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| J Immunol 189(3):1133-43. doi: 10.4049/jimmunol.1003406. Epub 2012 Jun 27.
2012
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| 17 | CTSB
|
| Cathepsin B inhibition limits bone metastasis in breast cancer.
|
| Withana NP, Blum G, Sameni M, Slaney C, Anbalagan A, Olive MB, Bidwell BN, Edgington L, Wang L, Moin K, Sloane BF, Anderson RL, Bogyo MS, Parker BS.
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| Cancer Res 72(5):1199-209. doi: 10.1158/0008-5472.CAN-11-2759. Epub 2012 Jan 19.
2012
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| 18 | CTSB, CTSK, CTSL, CTSS
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| Cysteine cathepsin S processes leptin, inactivating its biological activity.
|
| Oliveira M, Assis DM, Paschoalin T, Miranda A, Ribeiro EB, Juliano MA, Brömme D, Christoffolete MA, Barros NM, Carmona AK.
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| J Endocrinol 214(2):217-24. doi: 10.1530/JOE-12-0108. Epub 2012 May 31.
2012
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| 19 | CTSB, CTSS
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| Cathepsins (S and B) and their inhibitor Cystatin C in immune cells: modulation by interferon-β and role played in cell migration.
|
| Staun-Ram E, Miller A.
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| J Neuroimmunol 232(1-2):200-6. doi: 10.1016/j.jneuroim.2010.10.015. Epub 2010 Nov 26.
2011
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| 20 | BID, CTSB, SPARC
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| Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells.
|
| Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka S.
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| Cell Death Differ 17(10):1529-39. Epub 2010 Mar 26.
2010
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| 21 | CTSB, CTSZ
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| Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
|
| Sevenich L, Schurigt U, Sachse K, Gajda M, Werner F, Müller S, Vasiljeva O, Schwinde A, Klemm N, Deussing J, Peters C, Reinheckel T.
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| Proc Natl Acad Sci U S A 107(6):2497-502. Epub 2010 Jan 21.
2010
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| 22 | CTSB
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| Cathepsin B is a target of Hedgehog signaling in pancreatic cancer.
|
| Hwang JH, Lee SH, Lee KH, Lee KY, Kim H, Ryu JK, Yoon YB, Kim YT.
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| Cancer Lett 273(2):266-72. Epub 2008 Nov 11.PMID: 19004543 2009
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| 23 | BID, CTSB
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| Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells.
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| Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB.
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| Cell Death Differ 15(1):171-82. Epub 2007 Oct 5.
2008
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| 24 | CTSB
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| Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes.
|
| Büth H, Luigi Buttigieg P, Ostafe R, Rehders M, Dannenmann SR, Schaschke N, Stark HJ, Boukamp P, Brix K.
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| Eur J Cell Biol 86(11-12):747-61. Epub 2007 Jul 24.PMID: 17651862 2007
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| 25 | CTSB, SHKBP1
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| Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.
|
| Liu JP, Liu NS, Yuan HY, Guo Q, Lu H, Li YY.
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| Mol Cell Biochem 292(1-2):189-95.
2006
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| 26 | CTSB, ADAMTSL4
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| Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90.
|
| Liu J, Guo Q, Chen B, Yu Y, Lu H, Li YY.
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| FEBS Lett 580(1):245-50. Epub 2005 Dec 12. 2006
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| 27 | CTSB
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| Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH.
|
| Jane DT, Morvay L, Dasilva L, Cavallo-Medved D, Sloane BF, Dufresne MJ.
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| Biol Chem 387(2):223-34. 2006
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| 28 | CTSB, CTSL
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| The importance of cysteine cathepsin proteases for placental development.
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| Varanou A, Withington SL, Lakasing L, Williamson C, Burton GJ, Hemberger M.
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| J Mol Med 84(4):305-17. Epub 2006 Jan 27. 2006
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| 29 | CTSB
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| Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death.
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| Muntener K, Zwicky R, Csucs G, Rohrer J, Baici A.
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| J Biol Chem 279(39):41012-7. Epub 2004 Jul 15. 2004
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| 30 | CTSB
|
| Involvement of cathepsin B in the motor neuron degeneration of amyotrophic lateral sclerosis.
|
| Kikuchi H, Yamada T, Furuya H, Doh-ura K, Ohyagi Y, Iwaki T, Kira J.
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| Acta Neuropathol (Berl) 105(5):462-8. Epub 2003 Jan 29. 2003
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| 31 | CTSB
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| Evidence for the involvement of cathepsin B in skeletal myoblast differentiation.
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| Jane DT, DaSilva L, Koblinski J, Horwitz M, Sloane BF, Dufresne MJ.
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| J Cell Biochem 84(3):520-31. 2002
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| 32 | CTSB, TNC
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| Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas.
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| Mai J, Sameni M, Mikkelsen T, Sloane BF.
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| Biol Chem 383(9):1407-13. 2002
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| 33 | CTSB
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| Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes.
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| Zwicky R, Muntener K, Goldring MB, Baici A.
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| Biochem J 367(Pt 1):209-17. 2002
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| 34 | CTSB, CST3
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| Expression of cathepsin B and cystatin C in human colorectal cancer.
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| Hirai K, et al.
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| Hum Pathol 30(6):680-6. 1999
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| 35 | CTSB, CTSH, CTSK, CTSL
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| Cathepsin expression during skeletal development.
|
| Soderstrom M, et al.
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| Biochim Biophys Acta 1446(1-2):35-46 1999
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| 36 | CTSB, EPM1
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| Novel cystatin B mutation and diagnostic PCR assay in an Unverricht-Lundborg progressive myoclonus epilepsy patient.
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| Bespalova IN, Adkins S, Pranzatelli M, Burmeister M.
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| Am J Med Genet 74(5):467-71. 1997
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| 37 | CTSB
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| Confirmation of the human cathepsin B gene (CTSB) assignment to chromosome 8.
|
| Fong D, et al.
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| Hum Genet 89 : 10-12. 1992
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| 38 | CTSB
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| Alzheimer's disease amyloid beta-clipping enzyme (APP secretase) : identification, purification, and characterization of the enzyme.
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| Tagawa K, et al.
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| Biochem Biophys Res Commun 177 : 377-387. 1991
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| 39 | CTSB
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| Identification of renal cathepsin B as a human prorenin-processing enzyme.
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| Wang PH, et al.
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| J Biol Chem 266 : 12633-12638. 1991
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| 40 | CTSB
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| A TaqI DNA polymorphism in the human cathepsin B gene (CTSB).
|
| Hsieh WT, et al.
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| Nucleic Acids Res 18 : 3430. 1990
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| 41 | CTSB
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| In situ hybridization of a cathepsin B murine probe on the human chromosomes.
|
| Bouyon C, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 966. 1989
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| 42 | CTSB, CTSH
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| Chromosome assignment of cathepsin B (CTSB) to 8p22 and cathepsin H (CTSH) to 15q24-q25.
|
| Wang X, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 710. 1987
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| 43 | CTSB
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| Isolation of a cDNA clone for the human lysosomal proteinase cathepsin B.
|
| Fong D, et al.
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| Proc Natl Acad Sci U S A 83 : 2909-2913. 1986
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| 44 | CTSB, CTSD
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| Partial deficiency of cathepsins B and H in two human fibroblast cell lines with chromosome 11 abnormalities.
|
| Murnane MJ, et al.
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| Genetics 110 : s35. 1985
|