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| mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth ( | |
mice homozygous for the c-abl mutation are severely affected, displaying increased perinatal mortality, runtedness, and abnormal spleen, head, eye development, and major reductions in B cell progenitors ( |
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Abl-/- mice are osteoporotic with long bones containing thinner cortical bone and reduced trabecular bone volume ( |
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c-Abl deficiency result in a broad spectrum of defects in cell response to genotoxic stress, including activation of Chk1 and Chk2, activation of p53, nuclear foci formation, apoptosis, and DNA repair ( |