Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ABCB1

contributors: mct - updated : 07-09-2021

HGNC name	ATP-binding cassette, sub-family B (MDR/TAP), member 1
HGNC id	40

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     amplified in sarcoma cell lines tumoral     --over   in acute myeloid leukemia and cancer cell lines tumoral     --low   low ABCB1/low BAALC expression identifies a subgroup of intermediate cytogenetic risk AML patients with a remarkably good long-term outcome achieved by chemotherapy alone tumoral     --low   in breast tumors was associated with triple-negative subtype tumoral     --low   may promote colorectal carcinogenesis through increasing intracellular exposure to carcinogenic ABCB1 substrates

Susceptibility

to inflammatory bowel disease(IBD) to renal epithelial tumors

Variant & Polymorphism other	Ala893 increases the risk of IBD
	C3435T increases the risk of renal tumors

Candidate gene
Marker	EPS8, as ABCB1 and WT1, may be a clinically valuable biomarker for assessing the outcome of acute lymphoblastic leukemia (ALL) patients
Therapy target

ANIMAL & CELL MODELS