| 1 | ABCB1, CYP3A5
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| Genetic diversity of CYP3A5 and ABCB1 variants in East-Central and South European populations.
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| Adler G, Uzar I, Valjevac A, Kiseljakovic E, Mahmutbegovic E, Salkic NN, Adler MA, Mahmutbegovic N.
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| Ann Hum Biol. Jun;49(3-4):210-215. doi: 10.1080/03014460.2022.2100477. Epub 2022 Aug 10. 2022
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| 2 | ABCB1
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| ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux.
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| Margier M, Collet X, le May C, Desmarchelier C, André F, Lebrun C, Defoort C, Bluteau A, Borel P, Lespine A, Reboul E.
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| FASEB J. Feb;33(2):2084-2094. doi: 10.1096/fj.201800956R. Epub 2018 Sep 17 2019
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| 3 | ABCB1
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| P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease.
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| Sita G, Hrelia P, Tarozzi A, Morroni F.
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| Oxid Med Cell Longev. 2017:7905486. doi: 10.1155/2017/7905486. Epub 2017 Nov 26 2017
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| 4 | ABCB1
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| Loss of constitutive ABCB1 expression in breast cancer associated with worse prognosis.
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| Delou JMA, Vignal GM, Índio-do-Brasil V, Accioly MTS, da Silva TSL, Piranda DN, Sobral-Leite M, de Carvalho MA, Capella MAM, Vianna-Jorge R.
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| Breast Cancer (Dove Med Press) Jun 10;9:415-428. doi: 10.2147/BCTT.S131284. eCollection 2017 2017
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| 5 | ABCB1, TLR4
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| ABCB1 transporter and Toll-like receptor 4 in trabecular meshwork cells.
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| Grybauskas A, Koga T, Kuprys PV, Nolan M, McCarty R, Walker L, Green KA, Norkett WM, Yue BY, Knepper PA.
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| Mol Vis. Mar 5;21:201-12. eCollection 2015 2015
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| 6 | ABCB1, EPS8, WT1
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| Overexpression of EPS8 is associated with poor prognosis in patients with acute lymphoblastic leukemia.
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| He YZ, Liang Z, Wu MR, Wen Q, Deng L, Song CY, Wu BY, Tu SF, Huang R, Li YH.
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| Leuk Res. Jun;39(6):575-81. doi: 10.1016/j.leukres.2015.03.007. Epub 2015 Mar 20. 2015
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| 7 | ABCB1, BAALC
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| Low MDR1 and BAALC expression identifies a new subgroup of intermediate cytogenetic risk acute myeloid leukemia with a favorable outcome.
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| Guo X, Shi P, Chen F, Zha J, Liu B, Li R, Dong H, Zheng H, Xu B.
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| Blood Cells Mol Dis 53(3):144-8. doi: 10.1016/j.bcmd.2014.05.001. Epub 2014 May 20.
2014
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| 8 | ABCB1, PPP2R3C
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| Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.
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| Katayama K, Yamaguchi M, Noguchi K, Sugimoto Y.
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| Cancer Lett. Apr 1;345(1):124-31. doi: 10.1016/j.canlet.2013.12.007. Epub 2013 Dec 11 2014
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| 9 | ABCB1
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| Low ABCB1 gene expression is an early event in colorectal carcinogenesis.
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| Andersen V, Vogel U, Godiksen S, Frenzel FB, Sæbø M, Hamfjord J, Kure E, Vogel LK.
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| PLoS One. Aug 19;8(8):e72119. doi: 10.1371/journal.pone.0072119. eCollection 2013. 2013
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| 10 | ABCB1, APEX1, YBX1
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| Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1.
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| Sengupta S, Mantha AK, Mitra S, Bhakat KK.
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| Oncogene 30(4):482-93. Epub 2010 Sep 20.
2011
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| 11 | ABCB1, OCLN, PTK2, TJP1
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| P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK).
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| Su L, Mruk DD, Lui WY, Lee WM, Cheng CY.
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| Proc Natl Acad Sci U S A 108(49):19623-8. doi: 10.1073/pnas.1111414108. Epub 2011 Nov 21.
2011
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| 12 | ABCB1, ABCC2
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| Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2.
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| Ito K, Hoekstra D, van Ijzendoorn SC.
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| FEBS Lett 582(30):4153-7. Epub 2008 Nov 25.
2008
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| 13 | ABCB1, ABCC1, ABCG2
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| ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS.
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| Daood M, Tsai C, Ahdab-Barmada M, Watchko JF.
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| Neuropediatrics 39(4):211-8. Epub 2009 Jan 22.PMID: 19165709 2008
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| 14 | ABCB1
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| Thyroid hormone receptor mediates human MDR1 gene expression-Identification of the response region essential for gene expression.
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| Kurose K, Saeki M, Tohkin M, Hasegawa R.
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| Arch Biochem Biophys 474(1):82-90. Epub 2008 Mar 25.PMID: 18395509 2008
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| 15 | ABCB1
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| The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to alpha- and beta-tubulins.
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| Georges E.
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| Biochemistry 46(25):7337-42. Epub 2007 May 27.
2007
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| 16 | ABCB1
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| ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach.
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| Ho GT, Soranzo N, Nimmo ER, Tenesa A, Goldstein DB, Satsangi J.
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| Hum Mol Genet 15(5):797-805. Epub 2006 Jan 24. 2006
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| 17 | ABCB1, HSF1
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| Heat shock-independent induction of multidrug resistance by heat shock factor 1.
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| Tchénio T, Havard M, Martinez LA, Dautry F.
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| Mol Cell Biol 26(2):580-91.
2006
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| 18 | ABCB1
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| Characterization of ABC transporter ABCB1 expressed in human neural stem/progenitor cells.
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| Islam MO, Kanemura Y, Tajria J, Mori H, Kobayashi S, Shofuda T, Miyake J, Hara M, Yamasaki M, Okano H.
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| FEBS Lett 579(17):3473-80. 2005
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| 19 | RUNDC3B, ABCB1
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| Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis.
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| Raguz S, De Bella MT, Slade MJ, Higgins CF, Coombes RC, YagŸe E.
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| Int J Cancer 117(6):934-41. 2005
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| 20 | ABCB1, MVP, LRPPRC
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| New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP130 protein.
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| Labialle S, Dayan G, Gayet L, Rigal D, Gambrelle J, Baggetto LG.
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| Nucleic Acids Res 32(13):3864-76. Print 2004. 2004
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| 21 | ABCB1
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| MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.
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| Brant SR, Panhuysen CI, Nicolae D, Reddy DM, Bonen DK, Karaliukas R, Zhang L, Swanson E, Datta LW, Moran T, Ravenhill G, Duerr RH, Achkar JP, Karban AS, Cho JH.
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| Am J Hum Genet 73(6):1282-92. Epub 2003 Nov 07. 2003
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| 22 | ABCA7, ABCC1, ABCC2, ABCC3, ABCG1, ABCB1
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| Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization.
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| Kielar D, Kaminski WE, Liebisch G, Piehler A, Wenzel JJ, Mohle C, Heimerl S, Langmann T, Friedrich SO, Bottcher A, Barlage S, Drobnik W, Schmitz G.
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| J Invest Dermatol 121(3):465-74. 2003
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| 23 | ABCB1
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| Preferential expression of a mutant allele of the amplified MDR1 (ABCB1) gene in drug-resistant variants of a human sarcoma.
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| Chen GK, Lacayo NJ, Duran GE, Wang Y, Bangs CD, Rea S, Kovacs M, Cherry AM, Brown JM, Sikic BI.
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| Genes Chromosomes Cancer 34(4):372-83. 2002
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| 24 | ABCB1
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| Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors.
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| Siegsmund M, Brinkmann U, Schaffeler E, Weirich G, Schwab M, Eichelbaum M, Fritz P, Burk O, Decker J, Alken P, Rothenpieler U, Kerb R, Hoffmeyer S, Brauch H.
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| J Am Soc Nephrol 13(7):1847-54. 2002
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| 25 | ABCB1, ABCC1
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| Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.
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| Hegedus T, Orfi L, Seprodi A, Varadi A, Sarkadi B, Keri G.
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| Biochim Biophys Acta 1587(2-3):318-25. Review. 2002
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| 26 | ABCB1
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| Association of 5' CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells.
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| Kusaba H, et al.
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| Eur J Biochem 262(3):924-32 1999
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| 27 | ABCB1
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| Genetic polymorphism in MDR-1 : a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.
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| Mickley LA, et al.
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| Blood 91 : 1749-1756. 1998
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| 28 | ABCB1, ABCB4, ADAM22, DMTF1, CROT, NADHDL1, SCNEDL, SRI
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| Localization of 67 exons on a YAC contig spanning 1.5 Mb around the multidrug resistance gene region of human chromosome 7q21.1.
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| Torigoe K, et al.
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| Genomics 49 : 14-22. 1998
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| 29 | ABCB1
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| Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDRI/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL.
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| Knutsen T, Mickley LA, Ried T, Green ED, du Manoir S, Schrock E, Macville M, Ning Y, Robey R, Polymeropoulos M, Torres R, Fojo T.
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| Genes Chromosomes Cancer 23 : 44-54. 1998
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| 30 | ABCB1
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| Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias.
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| Nakayama M, Wada M, Harada T, Nagayama J, Kusaba H, Ohshima K, Kozuru M, Komatsu H, Ueda R, Kuwano M.
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| Blood 92 : 4296-4307. 1998
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| 31 | NFYA, ABCB1
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| Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.
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| Jin S, et al.
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| Mol Cell Biol 18(7):4377-84. 1998
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| 32 | ABCB5, ABCB1
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| MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.
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| Van Helvoort A, et al.
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| Cell 87 : 507-517. 1996
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| 33 | ABCB1
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| The human mdr1 (multidrug-resistance) gene harbours a long homopyrimidine homopurine sequence next to a cluster of Alu repeated sequences in intron 14.
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| Pauly M, et al.
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| Gene 153 : 299-300. 1995
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| 34 | MDRE, ABCB1, ABCB4, SLC5A1, SLC5A2, SLC6A1, SLC6A2, SLC6A4, SLC6A6, SLC6A8, SLC6A9
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| Molecular characterization of neurotransmitter transporters.
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| Shafqat S, et al.
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| Mol Endocrinol 7 : 1517-1529. 1993
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| 35 | ABCB1
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| Quantitative expression patterns of multidrug-resistance P-glycoprotein (MDR1) and differentially spliced cystic-fibrosis transmembrane-conductance regulator mRNA transcripts in human epithelia.
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| Bremer S, et al.
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| Eur J Biochem 206 : 137-149. 1992
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| 36 | ABCB1
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| Appearance and detection of multiple copies of the mdr-1 gene in clinical samples of mammary carcinoma.
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| Lšnn U, et al.
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| Int J Cancer 51 : 682-686. 1992
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| 37 | ABCB1
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| Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.
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| Devine SE, et al.
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| Proc Natl Acad Sci U S A 89 : 4564-4568. 1992
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| 38 | ABCB1
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| Primer-dependent amplification of mdr1 mRNA by polymerase chain reaction.
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| Sugawara I, et al.
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| Jpn J Cancer Res 83 : 131-133. 1992
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| 39 | ABCB1
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| PCR-determined expression of the MDR1 gene in chronic lymphocytic leukemia.
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| Rochlitz CF, et al.
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| Ann Hematol 65 : 241-246. 1992
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| 40 | ABCB1
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| Analysis of multidrug resistance (MDR-1) gene expression in chronic lymphocytic leukemia (CLL).
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| Shustik C, et al.
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| Br J Haematol 79 : 50-56. 1991
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| 41 | ABCB1, ABCB4
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| Structure of the human MDR3 gene and physical mapping of the human MDR locus.
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| Lincke CR, et al.
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| J Biol Chem 266 : 5303-5310. 1991
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| 42 | ABCB1, ABCB4
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| MspI/HpaII polymorphism in the human multidrug resistance gene 1.
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| Haber DA, et al.
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| Nucleic Acids Res 17 : 10142. 1989
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| 43 | ABCB1, ABCB4
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| Structure and expression of the human MDR (P-glycoprotein) gene family.
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| Chin JE, et al.
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| Mol Cell Biol 9 : 3808-3820. 1989
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| 44 | ABCB1, ABCB4
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| Utility of the polymerase chain reaction in detection of gene expression in drug-resistant human tumors.
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| Scanlon KJ, et al.
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| J Clin Lab Analysis 3 : 323-329. 1989
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| 45 | ABCB1, ABCB4
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| A polymorphic HindIII site within the human multidrug resistance gene 1 (MDR1).
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| Yoshimoto K, Iwahana H, Yokogoshi Y, Saito S, Shiraishi M, Sekiya T, Gottesman MM, Pastan I.
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| Nucleic Acids Res 16 : 11850. 1988
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| 46 | ABCB1, ABCB4
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| Detection of drug resistance in human tumors by in vitro enzymatic amplification.
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| Kashani-Sabet M, et al.
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| Cancer Res 48 : 5775-5778. 1988
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| 47 | ABCB1, ABCB4
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| Clarification of the chromosomal assignment of the human P-glycoprotein/MDR1 gene (PGY1).
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| Trent JM, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 705. 1987
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| 48 | ABCB1, ABCB4
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| Detection of a multidrug resistant phenotype in acute non-lymphoblastic leukaemia.
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| Ma DDF, et al.
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| Lancet I : 135-137. 1987
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| 49 | CFTR, MET, ABCB1, ABCB4
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| Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7.
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| Zengerling S, et al.
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| Am J Hum Genet 40 : 228-236. 1987
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| 50 | ABCB1, ABCB4
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| Chromosomal location of human P-glycoprotein gene sequences.
|
| Bell DR, et al.
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| Cancer Genet Cytogenet 25 : 141-148. 1987
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| 51 | ABCB1, ABCB4
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| Clarification of the chromosomal assignment of the human P-glycoprotein/mdr1 gene : possible coincidence with the cystic fibrosis and c-met oncogene.
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| Trent JM, et al.
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| Cancer Genet Cytogenet 26 : 187-190. 1987
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| 52 | ABCB1, ABCB4
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| RFLPs associated with MDR2, a member of the human multidrug resistance gene family mapped to chromosome 7.
|
| Choi K, et al.
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| Nucleic Acids Res 15 : 6305. 1987
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| 53 | ABCB1, ABCB4
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| Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.
|
| Callen DF, et al.
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| Hum Genet 77 : 142-144. 1987
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| 54 | ABCB1, ABCB4
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| The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein.
|
| Ueda K, et al.
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| Biochem Biophys Res Commun 141 : 956-962. 1986
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| 55 | ABCB1, ABCB4
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| Localization of multidrug resistance-associated DNA sequences to human chromosome 7.
|
| Fojo A, et al.
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| Somat Cell Mol Genet 12 : 415-420. 1986
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| 56 | ABCB1, ABCB4
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| Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.
|
| Shen DW, et al.
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| Mol Cell Biol 6 : 4039-4045. 1986
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| 57 | ABCB1, ABCB4
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| Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.
|
| Chen C, et al.
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| Cell 47 : 381-389. 1986
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| 58 | ABCB1, ABCB4
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| Chromosomal localization in normal human cells and CHO cells of asequence derived from P-glycoprotein (PGY1).
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| Trent J, et al.
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| (HGM8) Cytogenet Cell Genet 40 : 761-762. 1985
|