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FLASH GENE

Symbol

HOXA5

contributors: mct - updated : 19-05-2012

HGNC name	homeobox A5
HGNC id	5106

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in nearly 70 p100 of all breast carcinomas tumoral     --low   by hypermethylation in acute myeloid leukemia, but low level of HOXA5 hypermethylation is associated with short-term outcome constitutional   deletion     leads to anterior forelimb defects resulting from derepression of SHH expression

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene of androgen-mediated promoter methylation
Marker
Therapy target

ANIMAL & CELL MODELS

deregulation of the estrous cycle and the presence of ovarian epithelial cysts in Hoxa5(-/-) older murine females correlate with a reduced expression of specific epidermal growth factor receptor signaling components, namely Egfr, Areg, and Btc