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FLASH GENE
Symbol HOXA5 contributors: mct - updated : 19-05-2012
HGNC name homeobox A5
HGNC id 5106
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA binding domain
  • a protein transduction domain, with a role in protein transduction that may be useful in the suppression of vascular activation or vascular inflammatory disorders
    • secondary structure helix-turn-helix
    HOMOLOGY
    interspecies homolog to rattus Hoxa5 (97.8 pc)
    homolog to murine Hoxa5 (97.8 pc)
    intraspecies paralog to HOXB5
    Homologene
    FAMILY
  • Antp homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in the developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • upregulating both TP53 promoter-reporter constructs and endogenous P53 synthesis
  • inhibiting erythropoiesis
  • promoting myelopoiesis
  • involved in the regulation of hematopoietic lineage determination and maturation
  • central role for HOXA5 in coordinating a stable vascular phenotype
  • playing an important role in tumorigenesis step in growth and homeostasis in breast cells
  • absent in activated angiogenic endothelial cells and can block angiogenesis
  • can specifically activate the pleiotrophin promoter
  • regulates both TP53 and progesterone receptor expression levels in breast cancer cells
  • may play a role in maintaining the differentiated state within the breast epithelium
  • stroma-specific gene, playing a significant role in ovarian biology and may be involved in ovarian cancer predisposition
  • HOXA5 and HOXC5, control diverse aspects of phrenic motor column (PMC) development including their clustering, intramuscular branching, and survival
  • HOXA5 and HOXB5 paralog genes shared some functions during lung morphogenesis, but HOXA5 playing a predominant role
  • is required for forelimb anterior patterning
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding specifically to the motif 5'-CYYNATTA[TG]Y-3'
  • binding to its own promoter
    • RNA
    small molecule
    protein
  • TP53, PR
  • transactivator of progesterone receptor
  • interacts with promyelocytic leukemia zinc finger (ZBTB16) biochemically and genetically to restrict SHH expression
    • cell & other
    REGULATION
    activated by transcriptionally activated by all-trans retinoic acid (RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in nearly 70 p100 of all breast carcinomas
    tumoral     --low  
    by hypermethylation in acute myeloid leukemia, but low level of HOXA5 hypermethylation is associated with short-term outcome
    constitutional   deletion    
    leads to anterior forelimb defects resulting from derepression of SHH expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene of androgen-mediated promoter methylation
    • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deregulation of the estrous cycle and the presence of ovarian epithelial cysts in Hoxa5(-/-) older murine females correlate with a reduced expression of specific epidermal growth factor receptor signaling components, namely Egfr, Areg, and Btc