SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,organelle,mitochondria,outer
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,cytosolic,granule
|
| intracellular,nucleus,nucleoplasm
|
basic FUNCTION
| provide G6P for the synthesis of glycogen |
|
pancreatic glucokinase plays an important role in modulating insulin secretion |
|
glucose specific, primary regulator of glucose-controlled insulin secretion, catalyzing the first step of glycolysis, energy pathway |
|
regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein, GCKR |
|
role for posttranslational regulation of GCK S-nitrosylation as a vital regulatory mechanism for glucose-stimulated insulin secretion |
|
acts as a sensor of blood glucose levels in the pancreas, and a few other cells of the gut and brain, and as the rate-limiting step in glucose metabolism in the liver |
|
maintains glucose homeostasis by displaying a sigmoidal kinetic response to increasing blood glucose levels ( |
|
|
|
GCK and GCKR function as key glucose sensors ( |
|
|