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FLASH GENE
Symbol IGFBP3 contributors: mct/shn/pgu - updated : 02-04-2025
HGNC name insulin-like growth factor binding protein 3
HGNC id 5472
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in acromegalic patients
tumoral     --low  
in breast cancer
tumoral     --over  
high expression of IGFBP-3 is associated with a low risk of cancer, whereas low expression of IGFBP3 increases the risk of cancer
tumoral     --low  
in colorectal carcinoma (CRC) due to promoter methylations
Susceptibility
  • prostate cancer with advanced stage
  • to breast cancer
    • Variant & Polymorphism
  • C allele may cumulatively increase the risk for prostate cancer metastasis and for having tumors with a biologically more aggressive phenotype
  • homozygosity for the variant allele in polymorphisms A-202C, G227C, 5606InsA, and C5827T associated with the level of blood IGFBP-3 protein and increasing the risk of breast cancer
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    may thus be useful target for improved and more individualized treatments for patients with esophageal squamous cell carcinoma
    neurosensorialvisualretina
    use of exogenous IGFBP3 in patients at risk for retinal neovascularization would have protective effects (suppresses retinopathy of prematurity through suppression of oxygen-induced vessel loss and promotion of vascular regrowth)
    cardiovascularatheroma 
    potentially a therapeutic target for treatment of ischemic conditions
    cancer  
    is a new type of cancer therapy that inhibits cancer proliferation by inducing senescence
    diabetetype 1 
    IGFBP3/TMEM219 targeting may therefore serve as a therapeutic option in diabetes
    ANIMAL & CELL MODELS
  • GFBP3-deficient mice displa a dose-dependent increase in oxygen-induced retinal vessel loss and Igfbp3(-/-) mice had a 31% decrease in retinal vessel regrowth versus controls after returning to room air (