| 1 | IGFBP3, KPNB1, MTRNR2L1
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| Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
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| Njomen E, Evans HG, Gedara SH, Heyl DL.
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| Protein Pept Lett 22(10):869-76.
2015
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| 2 | IGFBP3, NR4A1
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| IGFBP-3 may trigger osteoarthritis by inducing apoptosis of chondrocytes through Nur77 translocation.
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| Wei Z, Li HH.
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| Int J Clin Exp Pathol 8(12):15599-610. eCollection 2015.
2015
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| 3 | CD5L, IGFBP2, IGFBP3, IGFBP4
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| Interaction of AIM with insulin-like growth factor-binding protein-4.
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| You Q, Wu Y, Yao N, Shen G, Zhang Y, Xu L, Li G, Ju C.
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| Int J Mol Med 36(3):833-8. doi: 10.3892/ijmm.2015.2262. Epub 2015 Jun 26.
2015
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| 4 | IGFBP3, VDR
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| Insulin-like growth factor binding protein-3 modulates osteoblast differentiation via interaction with vitamin D receptor.
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| Li J, Jin D, Fu S, Mei G, Zhou J, Lei L, Yu B, Wang G.
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| Biochem Biophys Res Commun 436(4):632-7. doi: 10.1016/j.bbrc.2013.04.111. Epub 2013 Jun 11.
2013
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| 5 | IGFBP3, PLAT, SERPINE1
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| Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.
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| Elzi DJ, Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y.
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| Proc Natl Acad Sci U S A 109(30):12052-7. doi: 10.1073/pnas.1120437109. Epub 2012 Jul 9.
2012
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| 6 | BAG1, IGFBP3
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| IGFBP3 and BAG1 enhance radiation-induced apoptosis in squamous esophageal cancer cells.
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| Yoshino K, Motoyama S, Koyota S, Shibuya K, Usami S, Maruyama K, Saito H, Minamiya Y, Sugiyama T, Ogawa J.
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| Biochem Biophys Res Commun 404(4):1070-5. Epub 2010 Dec 30.
2011
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| 7 | IGFBP3
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| Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).
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| Kielczewski JL, Li Calzi S, Shaw LC, Cai J, Qi X, Ruan Q, Wu L, Liu L, Hu P, Chan-Ling T, Mames RN, Firth S, Baxter RC, Turowski P, Busik JV, Boulton ME, Grant MB.
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| Invest Ophthalmol Vis Sci. 52(11):8278-86. 2011
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| 8 | BMP1, IGFBP3
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| Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3.
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| Kim B, Huang G, Ho WB, Greenspan DS.
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| J Biol Chem 286(33):29014-25. Epub 2011 Jun 22.
2011
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| 9 | IGFBP3
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| IGFBP-3 is a metastasis suppression gene in prostate cancer.
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| Mehta HH, Gao Q, Galet C, Paharkova V, Wan J, Said J, Sohn JJ, Lawson G, Cohen P, Cobb LJ, Lee KW.
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| Cancer Res 71(15):5154-63. Epub 2011 Jun 22.
2011
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| 10 | IGFBP3, MXI1
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| Mxi1 regulates cell proliferation through insulin-like growth factor binding protein-3.
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| Ko JY, Yoo KH, Lee HW, Park JH.
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| Biochem Biophys Res Commun 415(1):36-41. doi: 10.1016/j.bbrc.2011.10.005. Epub 2011 Oct 7.
2011
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| 11 | IGF1, IGFBP3
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| Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.
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| Hoyo C, Grubber J, Demark-Wahnefried W, Lobaugh B, Jeffreys AS, Grambow SC, Marks JR, Keku TO, Walther PJ, Schildkraut JM.
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| J Natl Med Assoc 101(7):711-6.
2009
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| 12 | IGFBP3, RXRA, TNF
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| IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription.
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| Zappalà G, Rechler MM.
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| Biochem Biophys Res Commun 382(4):785-9. Epub 2009 Mar 24.
2009
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| 13 | HCRT, IGFBP3
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| IGFBP3 colocalizes with and regulates hypocretin (orexin).
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| Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E.
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| PLoS One 4(1):e4254. Epub 2009 Jan 22.
2009
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| 14 | IGFBP3, IGFBP5
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| IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin.
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| Beattie J, Kreiner M, Allan GJ, Flint DJ, Domingues D, van der Walle CF.
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| Biochem Biophys Res Commun 381(4):572-6. Epub 2009 Feb 21.
2009
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| 15 | IGFBP3
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| NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation.
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| Muhlbradt E, Asatiani E, Ortner E, Wang A, Gelmann EP.
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| Cancer Res. 69(6):2615-22. 2009
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| 16 | IGFBP3, RXRA
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| Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha.
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| Zappala G, Elbi C, Edwards J, Gorenstein J, Rechler MM, Bhattacharyya N.
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| Endocrinology 149(4):1802-12. Epub 2007 Dec 27.
2008
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| 17 | IGFBP3
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| Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma.
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| Torng PL, Lee YC, Huang CY, Ye JH, Lin YS, Chu YW, Huang SC, Cohen P, Wu CW, Lin CT.
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| Oncogene 27(15):2137-47. Epub 2007 Oct 22.PMID: 17952116 2008
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| 18 | GHR,IGFBP3
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| Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer.
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| Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Kaprara A, Blakeman J, Vainas I, Mpousoulegas A, Williams CJ, Mantzoros C.
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| Eur J Endocrinol 156(2):187-94. 2007
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| 19 | IGFBP3
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| Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers.
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| Tomii K, Tsukuda K, Toyooka S, Dote H, Hanafusa T, Asano H, Naitou M, Doihara H, Kisimoto T, Katayama H, Pass HI, Date H, Shimizu N.
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| Int J Cancer 120(3):566-73. 2007
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| 20 | IGFBP3
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| From the Cover: IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.
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| Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE.
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| Proc Natl Acad Sci U S A 104(25):10589-94. Epub 2007 Jun 13. 2007
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| 21 | IGFBP3
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| IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development.
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| Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Calzi SL, Sullivan SM, Grant MB.
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| Proc Natl Acad Sci U S A 104(25):10595-600. Epub 2007 Jun 13. 2007
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| 22 | IGFALS, IGF1R, IGFBP3, IGF1
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| Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study.
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| Deming SL, Ren Z, Wen W, Shu XO, Cai Q, Gao YT, Zheng W.
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| Breast Cancer Res Treat 104(3):309-19. Epub 2006 Oct 25. 2007
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| 23 | CDX2, IGFBP3
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| CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3.
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| Chun SY, Chen F, Washburn JG, MacDonald JW, Innes KL, Zhao R, Cruz-Correa MR, Dang LH, Dang DT.
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| Oncogene 26(32):4725-9. Epub 2007 Feb 5.
2007
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| 24 | IGFBP3, RARA, RXRA
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| Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: role in modulation of RAR-signaling.
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| Schedlich LJ, Graham LD, O'Han MK, Muthukaruppan A, Yan X, Firth SM, Baxter RC.
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| Arch Biochem Biophys 465(2):359-69. Epub 2007 Jun 26.PMID: 17644060 2007
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| 25 | IGFBP3
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| IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53.
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| Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, Ogino S.
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| Neoplasia 9(12):1091-8.PMID: 18084616 2007
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| 26 | IGFBP3
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| Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.
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| Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P.
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| Carcinogenesis. 28(8):1653-8. 2007
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| 27 | IGFBP3
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| IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.
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| Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE.
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| Proc Natl Acad Sci U S A. 104(25):10589-94. 2007
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| 28 | IGF1, IGFBP3
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| IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer.
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| Al-Zahrani A, Sandhu MS, Luben RN, Thompson D, Baynes C, Pooley KA, Luccarini C, Munday H, Perkins B, Smith P, Pharoah PD, Wareham NJ, Easton DF, Ponder BA, Dunning AM.
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| Hum Mol Genet 15(1):1-10. Epub 2005 Nov 23. 2006
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| 29 | IGFBP3,NRN1,TXNIP
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| Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer.
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| Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Leger J, Corvol P, Germain S.
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| FEBS Lett 580(14):3395-400. Epub 2006 May 11. 2006
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| 30 | IGF1, IGFBP3
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| IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer.
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| Friedrichsen DM, Hawley S, Shu J, Humphrey M, Sabacan L, Iwasaki L, Etzioni R, Ostrander EA, Stanford JL.
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| Prostate 65(1):44-51. 2005
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| 31 | IGFBP3
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| IGFBP-3 expression in hepatocellular carcinoma involves abnormalities in TGF-beta and/or Rb signaling pathways.
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| Yumoto E, Nakatsukasa H, Hanafusa T, Yumoto Y, Nouso K, Matsumoto E, Onishi T, Takuma Y, Tanaka H, Fujikawa T, Suzuki M, Uemura M, Shiratori Y.
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| Int J Oncol 27(5):1223-30. 2005
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| 32 | IGFBP3
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| Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women.
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| Ren Z, Cai Q, Shu XO, Cai H, Li C, Yu H, Gao YT, Zheng W.
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| Cancer Epidemiol Biomarkers Prev 13(8):1290-5. 2004
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| 33 | IGFBP3
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| Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization.
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| Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP, Cohen P.
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| J Biol Chem. 279(1):469-76. 2004
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| 34 | IGFBP3
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| Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and inhibits the AMF/PGI function.
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| Mishra S, Raz A, Murphy LJ.
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| Cancer Res. 64(7):2516-22. 2004
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| 35 | IGFBP3
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| Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3.
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| Singh B, Charkowicz D, Mascarenhas D.
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| J Biol Chem. 279(1):477-87. 2004
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| 36 | IGFBP3
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| Functional cloning of IGFBP-3 from human microvascular endothelial cells reveals its novel role in promoting proliferation of primitive CD34+CD38- hematopoietic cells in vitro.
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| Liu LQ, Sposato M, Liu HY, Vaudrain T, Shi MJ, Rider K, Stevens Z, Visser J, Deng HK, Kraus M.
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| Oncol Res 13(6-10):359-71. 2003
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| 37 | IGFBP3
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| Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer.
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| Wang L, Habuchi T, Tsuchiya N, Mitsumori K, Ohyama C, Sato K, Kinoshita H, Kamoto T, Nakamura A, Ogawa O, Kato T.
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| Cancer Res 63(15):4407-11. 2003
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| 38 | IGFBP3
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| Type Ialpha collagen is an IGFBP-3 binding protein.
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| Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P.
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| Growth Horm IGF Res. 13(2-3):89-97. 2003
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| 39 | IGFBP3
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| Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1.
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| Gui Y, Murphy LJ.
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| Mol Cell Biochem. 250(1-2):189-95. 2003
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| 40 | IGFBP3
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| Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.
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| Ikonen M, Liu B, Hashimoto Y, Ma L, Lee KW, Niikura T, Nishimoto I, Cohen P.
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| Proc Natl Acad Sci U S A. 100(22):13042-7. 2003
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| 41 | IGFBP3
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| Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts.
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| Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE.
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| J Cell Physiol. 195(1):70-9. 2003
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| 42 | IGFBP3, STAT1
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| Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis.
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| Spagnoli A, Torello M, Nagalla SR, Horton WA, Pattee P, Hwa V, Chiarelli F, Roberts CT Jr, Rosenfeld RG.
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| J Biol Chem 277(21):18860-7. 2002
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| 43 | IGFBP3, IGFBP4, IGFBP5
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| Co-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilage.
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| Martin JA, Miller BA, Scherb MB, Lembke LA, Buckwalter JA.
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| Osteoarthritis Cartilage 10(7):556-63. 2002
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| 44 | IGFBP3
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| Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
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| Zwad O, Kübler B, Roth W, Scharf JG, Saftig P, Peters C, Braulke T.
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| FEBS Lett. 510(3):211-5. 2002
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| 45 | IGFBP3
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| Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation.
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| Rajah R, Lee KW, Cohen P.
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| Cell Growth Differ. 13(4):163-71. 2002
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| 46 | IGF1, IGFBP3
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| Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma.
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| Gui Y, Murphy LJ.
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| J Clin Endocrinol Metab. 86(5):2104-10. 2001
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| 47 | ADAM12, IGFBP3
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| ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3.
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| Shi Z, Xu W, Loechel F, Wewer UM, Murphy LJ.
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| J Biol Chem 275(24):18574-80. 2000
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| 48 | IGFBP3
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| Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis.
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| Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM, Cohen P.
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| J Biol Chem. 275(43):33607-13. 2000
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| 49 | IGFBP3
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| Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
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| Imai Y, Moralez A, Andag U, Clarke JB, Busby WH Jr, Clemmons DR.
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| J Biol Chem. 275(24):18188-94. 2000
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| 50 | IGFBP3
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| Changes in insulin-like growth factor-binding protein-3 messenger ribonucleic acid in endothelial cells of the human corpus luteum: a possible role in luteal development and rescue
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| Fraser HM, Lunn SF, Kim H, Duncan WC, Rodger FE, Illingworth PJ, Erickson GF
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| J Clin Endocrinol Metab. 85(4):1672-7. 2000
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| 51 | IGFBP1, IGFBP3
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| Screening for Mutations in the Promoter and the Coding Region of the IGFBP1 and IGFBP3 Genes in Silver-Russell Syndrome Patients1.
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| Eggermann K, et al.
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| Hum Hered 49(3):123-128. 1999
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| 52 | CCN3, CTGF, CYR61, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, IGFBP7
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| Novel Aspects of the Insulin-like Growth Factor Binding Proteins.
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| Wetterau LA, et al.
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| Mol Genet Metab 68(2):161-181 1999
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| 53 | IGFBP3
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| The role of IGF binding protein-3 as a parameter of activity in acromegalic patients.
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| Halperin I, Casamitjana R, Flores L, Fernandez-Balsells M, Vilardell E.
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| Eur J Endocrinol 141(2):145-8 1999
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| 54 | IGFBP3
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| The heparin binding domain of insulin-like growth factor binding protein (IGFBP)-3 increases susceptibility of IGFBP-3 to proteolysis.
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| Durham SK, Suwanichkul A, Hayes JD, Herington AC, Powell DR, Campbell PG.
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| Horm Metab Res. 31(2-3):216-25. 1999
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| 55 | IGFBP3
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| Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3.
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| Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR.
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| Am J Physiol. 275(2 Pt 1):E321-31. 1998
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| 56 | CCN3, CTGF, CYR61, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, IGFBP7
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| Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.
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| Kim HS, et al.
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| Proc Natl Acad Sci U S A 94 : 12981-12986. 1997
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| 57 | IGFBP3
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| Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action.
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| Mohseni-Zadeh S, Binoux M.
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| Endocrinology. 138(12):5645-8. 1997
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| 58 | IGFBP3
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| Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1(IGBP1) and 3(IGBP3) on chromosome 7.
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| Ehrenborg E, et al.
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| Genomics 12 : 497-502. 1992
|