Citations for
1IGFBP3, KPNB1, MTRNR2L1
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
Njomen E, Evans HG, Gedara SH, Heyl DL.
Protein Pept Lett 22(10):869-76. 2015
2IGFBP3, NR4A1
IGFBP-3 may trigger osteoarthritis by inducing apoptosis of chondrocytes through Nur77 translocation.
Wei Z, Li HH.
Int J Clin Exp Pathol 8(12):15599-610. eCollection 2015. 2015
3CD5L, IGFBP2, IGFBP3, IGFBP4
Interaction of AIM with insulin-like growth factor-binding protein-4.
You Q, Wu Y, Yao N, Shen G, Zhang Y, Xu L, Li G, Ju C.
Int J Mol Med 36(3):833-8. doi: 10.3892/ijmm.2015.2262. Epub 2015 Jun 26. 2015
4IGFBP3, VDR
Insulin-like growth factor binding protein-3 modulates osteoblast differentiation via interaction with vitamin D receptor.
Li J, Jin D, Fu S, Mei G, Zhou J, Lei L, Yu B, Wang G.
Biochem Biophys Res Commun 436(4):632-7. doi: 10.1016/j.bbrc.2013.04.111. Epub 2013 Jun 11. 2013
5IGFBP3, PLAT, SERPINE1
Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.
Elzi DJ, Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y.
Proc Natl Acad Sci U S A 109(30):12052-7. doi: 10.1073/pnas.1120437109. Epub 2012 Jul 9. 2012
6BAG1, IGFBP3
IGFBP3 and BAG1 enhance radiation-induced apoptosis in squamous esophageal cancer cells.
Yoshino K, Motoyama S, Koyota S, Shibuya K, Usami S, Maruyama K, Saito H, Minamiya Y, Sugiyama T, Ogawa J.
Biochem Biophys Res Commun 404(4):1070-5. Epub 2010 Dec 30. 2011
7IGFBP3
Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).
Kielczewski JL, Li Calzi S, Shaw LC, Cai J, Qi X, Ruan Q, Wu L, Liu L, Hu P, Chan-Ling T, Mames RN, Firth S, Baxter RC, Turowski P, Busik JV, Boulton ME, Grant MB.
Invest Ophthalmol Vis Sci. 52(11):8278-86. 2011
8BMP1, IGFBP3
Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3.
Kim B, Huang G, Ho WB, Greenspan DS.
J Biol Chem 286(33):29014-25. Epub 2011 Jun 22. 2011
9IGFBP3
IGFBP-3 is a metastasis suppression gene in prostate cancer.
Mehta HH, Gao Q, Galet C, Paharkova V, Wan J, Said J, Sohn JJ, Lawson G, Cohen P, Cobb LJ, Lee KW.
Cancer Res 71(15):5154-63. Epub 2011 Jun 22. 2011
10IGFBP3, MXI1
Mxi1 regulates cell proliferation through insulin-like growth factor binding protein-3.
Ko JY, Yoo KH, Lee HW, Park JH.
Biochem Biophys Res Commun 415(1):36-41. doi: 10.1016/j.bbrc.2011.10.005. Epub 2011 Oct 7. 2011
11IGF1, IGFBP3
Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.
Hoyo C, Grubber J, Demark-Wahnefried W, Lobaugh B, Jeffreys AS, Grambow SC, Marks JR, Keku TO, Walther PJ, Schildkraut JM.
J Natl Med Assoc 101(7):711-6. 2009
12IGFBP3, RXRA, TNF
IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription.
Zappalà G, Rechler MM.
Biochem Biophys Res Commun 382(4):785-9. Epub 2009 Mar 24. 2009
13HCRT, IGFBP3
IGFBP3 colocalizes with and regulates hypocretin (orexin).
Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E.
PLoS One 4(1):e4254. Epub 2009 Jan 22. 2009
14IGFBP3, IGFBP5
IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin.
Beattie J, Kreiner M, Allan GJ, Flint DJ, Domingues D, van der Walle CF.
Biochem Biophys Res Commun 381(4):572-6. Epub 2009 Feb 21. 2009
15IGFBP3
NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation.
Muhlbradt E, Asatiani E, Ortner E, Wang A, Gelmann EP.
Cancer Res. 69(6):2615-22. 2009
16IGFBP3, RXRA
Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha.
Zappala G, Elbi C, Edwards J, Gorenstein J, Rechler MM, Bhattacharyya N.
Endocrinology 149(4):1802-12. Epub 2007 Dec 27. 2008
17IGFBP3
Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma.
Torng PL, Lee YC, Huang CY, Ye JH, Lin YS, Chu YW, Huang SC, Cohen P, Wu CW, Lin CT.
Oncogene 27(15):2137-47. Epub 2007 Oct 22.PMID: 17952116 2008
18GHR,IGFBP3
Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer.
Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Kaprara A, Blakeman J, Vainas I, Mpousoulegas A, Williams CJ, Mantzoros C.
Eur J Endocrinol 156(2):187-94. 2007
19IGFBP3
Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers.
Tomii K, Tsukuda K, Toyooka S, Dote H, Hanafusa T, Asano H, Naitou M, Doihara H, Kisimoto T, Katayama H, Pass HI, Date H, Shimizu N.
Int J Cancer 120(3):566-73. 2007
20IGFBP3
From the Cover: IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.
Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE.
Proc Natl Acad Sci U S A 104(25):10589-94. Epub 2007 Jun 13. 2007
21IGFBP3
IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development.
Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Calzi SL, Sullivan SM, Grant MB.
Proc Natl Acad Sci U S A 104(25):10595-600. Epub 2007 Jun 13. 2007
22IGFALS, IGF1R, IGFBP3, IGF1
Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study.
Deming SL, Ren Z, Wen W, Shu XO, Cai Q, Gao YT, Zheng W.
Breast Cancer Res Treat 104(3):309-19. Epub 2006 Oct 25. 2007
23CDX2, IGFBP3
CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3.
Chun SY, Chen F, Washburn JG, MacDonald JW, Innes KL, Zhao R, Cruz-Correa MR, Dang LH, Dang DT.
Oncogene 26(32):4725-9. Epub 2007 Feb 5. 2007
24IGFBP3, RARA, RXRA
Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: role in modulation of RAR-signaling.
Schedlich LJ, Graham LD, O'Han MK, Muthukaruppan A, Yan X, Firth SM, Baxter RC.
Arch Biochem Biophys 465(2):359-69. Epub 2007 Jun 26.PMID: 17644060 2007
25IGFBP3
IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53.
Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, Ogino S.
Neoplasia 9(12):1091-8.PMID: 18084616 2007
26IGFBP3
Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.
Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P.
Carcinogenesis. 28(8):1653-8. 2007
27IGFBP3
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.
Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE.
Proc Natl Acad Sci U S A. 104(25):10589-94. 2007
28IGF1, IGFBP3
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer.
Al-Zahrani A, Sandhu MS, Luben RN, Thompson D, Baynes C, Pooley KA, Luccarini C, Munday H, Perkins B, Smith P, Pharoah PD, Wareham NJ, Easton DF, Ponder BA, Dunning AM.
Hum Mol Genet 15(1):1-10. Epub 2005 Nov 23. 2006
29IGFBP3,NRN1,TXNIP
Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer.
Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Leger J, Corvol P, Germain S.
FEBS Lett 580(14):3395-400. Epub 2006 May 11. 2006
30IGF1, IGFBP3
IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer.
Friedrichsen DM, Hawley S, Shu J, Humphrey M, Sabacan L, Iwasaki L, Etzioni R, Ostrander EA, Stanford JL.
Prostate 65(1):44-51. 2005
31IGFBP3
IGFBP-3 expression in hepatocellular carcinoma involves abnormalities in TGF-beta and/or Rb signaling pathways.
Yumoto E, Nakatsukasa H, Hanafusa T, Yumoto Y, Nouso K, Matsumoto E, Onishi T, Takuma Y, Tanaka H, Fujikawa T, Suzuki M, Uemura M, Shiratori Y.
Int J Oncol 27(5):1223-30. 2005
32IGFBP3
Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women.
Ren Z, Cai Q, Shu XO, Cai H, Li C, Yu H, Gao YT, Zheng W.
Cancer Epidemiol Biomarkers Prev 13(8):1290-5. 2004
33IGFBP3
Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization.
Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP, Cohen P.
J Biol Chem. 279(1):469-76. 2004
34IGFBP3
Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and inhibits the AMF/PGI function.
Mishra S, Raz A, Murphy LJ.
Cancer Res. 64(7):2516-22. 2004
35IGFBP3
Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3.
Singh B, Charkowicz D, Mascarenhas D.
J Biol Chem. 279(1):477-87. 2004
36IGFBP3
Functional cloning of IGFBP-3 from human microvascular endothelial cells reveals its novel role in promoting proliferation of primitive CD34+CD38- hematopoietic cells in vitro.
Liu LQ, Sposato M, Liu HY, Vaudrain T, Shi MJ, Rider K, Stevens Z, Visser J, Deng HK, Kraus M.
Oncol Res 13(6-10):359-71. 2003
37IGFBP3
Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer.
Wang L, Habuchi T, Tsuchiya N, Mitsumori K, Ohyama C, Sato K, Kinoshita H, Kamoto T, Nakamura A, Ogawa O, Kato T.
Cancer Res 63(15):4407-11. 2003
38IGFBP3
Type Ialpha collagen is an IGFBP-3 binding protein.
Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P.
Growth Horm IGF Res. 13(2-3):89-97. 2003
39IGFBP3
Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1.
Gui Y, Murphy LJ.
Mol Cell Biochem. 250(1-2):189-95. 2003
40IGFBP3
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.
Ikonen M, Liu B, Hashimoto Y, Ma L, Lee KW, Niikura T, Nishimoto I, Cohen P.
Proc Natl Acad Sci U S A. 100(22):13042-7. 2003
41IGFBP3
Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts.
Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE.
J Cell Physiol. 195(1):70-9. 2003
42IGFBP3, STAT1
Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis.
Spagnoli A, Torello M, Nagalla SR, Horton WA, Pattee P, Hwa V, Chiarelli F, Roberts CT Jr, Rosenfeld RG.
J Biol Chem 277(21):18860-7. 2002
43IGFBP3, IGFBP4, IGFBP5
Co-localization of insulin-like growth factor binding protein 3 and fibronectin in human articular cartilage.
Martin JA, Miller BA, Scherb MB, Lembke LA, Buckwalter JA.
Osteoarthritis Cartilage 10(7):556-63. 2002
44IGFBP3
Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts.
Zwad O, Kübler B, Roth W, Scharf JG, Saftig P, Peters C, Braulke T.
FEBS Lett. 510(3):211-5. 2002
45IGFBP3
Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation.
Rajah R, Lee KW, Cohen P.
Cell Growth Differ. 13(4):163-71. 2002
46IGF1, IGFBP3
Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma.
Gui Y, Murphy LJ.
J Clin Endocrinol Metab. 86(5):2104-10. 2001
47ADAM12, IGFBP3
ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3.
Shi Z, Xu W, Loechel F, Wewer UM, Murphy LJ.
J Biol Chem 275(24):18574-80. 2000
48IGFBP3
Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis.
Liu B, Lee HY, Weinzimer SA, Powell DR, Clifford JL, Kurie JM, Cohen P.
J Biol Chem. 275(43):33607-13. 2000
49IGFBP3
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
Imai Y, Moralez A, Andag U, Clarke JB, Busby WH Jr, Clemmons DR.
J Biol Chem. 275(24):18188-94. 2000
50IGFBP3
Changes in insulin-like growth factor-binding protein-3 messenger ribonucleic acid in endothelial cells of the human corpus luteum: a possible role in luteal development and rescue
Fraser HM, Lunn SF, Kim H, Duncan WC, Rodger FE, Illingworth PJ, Erickson GF
J Clin Endocrinol Metab. 85(4):1672-7. 2000
51IGFBP1, IGFBP3
Screening for Mutations in the Promoter and the Coding Region of the IGFBP1 and IGFBP3 Genes in Silver-Russell Syndrome Patients1.
Eggermann K, et al.
Hum Hered 49(3):123-128. 1999
52CCN3, CTGF, CYR61, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, IGFBP7
Novel Aspects of the Insulin-like Growth Factor Binding Proteins.
Wetterau LA, et al.
Mol Genet Metab 68(2):161-181 1999
53IGFBP3
The role of IGF binding protein-3 as a parameter of activity in acromegalic patients.
Halperin I, Casamitjana R, Flores L, Fernandez-Balsells M, Vilardell E.
Eur J Endocrinol 141(2):145-8 1999
54IGFBP3
The heparin binding domain of insulin-like growth factor binding protein (IGFBP)-3 increases susceptibility of IGFBP-3 to proteolysis.
Durham SK, Suwanichkul A, Hayes JD, Herington AC, Powell DR, Campbell PG.
Horm Metab Res. 31(2-3):216-25. 1999
55IGFBP3
Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3.
Campbell PG, Durham SK, Suwanichkul A, Hayes JD, Powell DR.
Am J Physiol. 275(2 Pt 1):E321-31. 1998
56CCN3, CTGF, CYR61, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, IGFBP7
Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily.
Kim HS, et al.
Proc Natl Acad Sci U S A 94 : 12981-12986. 1997
57IGFBP3
Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action.
Mohseni-Zadeh S, Binoux M.
Endocrinology. 138(12):5645-8. 1997
58IGFBP3
Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1(IGBP1) and 3(IGBP3) on chromosome 7.
Ehrenborg E, et al.
Genomics 12 : 497-502. 1992