| basic FUNCTION
| having a dithiol-disulfide oxidoreductase activity |
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participating in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide |
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catalyzing dithiol-disulfide exchange reactions |
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implicated in thioredoxin system may be an effective defense system protecting the lens against oxidative stress |
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having a little role in apoptosis of malignant mesothelioma cells |
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enhanced HIF-1alpha protein amount and facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation  |
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affects CD30-dependent changes in lymphocyte effector function |
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IFN-gamma-induced factor that may play a role in developing Th1 immunity and in the maintenance of immune homeostasis upon infection, radiation, and oxidative stress |
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multifunctional thiol protein that is critically involved in maintaining cellular redox homeostasis |
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has a role in suppressing senescence in normal cells in addition to its function as a redox-protective protein |
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reduce disulfide bonds and other thiol modifications in all cells using a CXXC motif |
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antiapoptotic and oncogenic potential of (secreted) TXN suggesting that it may exert effects in Tregs beyond redox regulation |
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TXN and TXN2 regulate the proliferation and survival of adipose tissue-derived mesenchymal stem cells, and these processes are mediated by the activation of ERK1/2 |
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important antioxidative enzyme in endothelial cells, required for apoptosis inhibition |
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denitrosylase that reverses NO inhibition of exocytosis |
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might regulate exocytosis in a variety of physiological settings, such as vascular inflammation, thrombosis, and insulin release |
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highly specific activator of oxidized human TGM2 |
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cellular redox protein that plays a central role in maintaining the redox state and modulates redox-regulated gene expression, consequently protecting cells from oxidative stress |
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is a potential candidate that could be involved in ADAM17 activity regulation |
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oxidoreductase activities of TXNDC17 complement those of TXN and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols |
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the catalytic site of TXN interacts with MAP3K5-TXN-binding domain(TBD) region containing cysteine C200 and the oxidative stress induces intramolecular disulfide bond formation within MAP3K5-TBD |
