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FLASH GENE

Symbol

CYP3A4

contributors: mct - updated : 05-04-2021

HGNC name	cytochrome P450, family 3, subfamily A, polypeptide 4
HGNC id	2637

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

Human Cytochrome P450 (CYP) Allele Nomenclature Committee

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in lung cancer constitutional       loss of function marked reduction of CYP3A4 activity among individuals with Crohn disease

Susceptibility

to prostate cancer to treatment-related leukemia

Variant & Polymorphism other	polymorphism CYP3A4V potentially increased susceptibility to prostate cancer
	CYP3A4-W genotype may be at increased risk for treatment-related leukemia
	CYP3A4-W genotype may increase production of potentially DNA-damaging reactive intermediates and may decrease production of the epipodophyllotoxin catechol metabolite, which is the precursor of the potentially DNA-damaging quinone
	CYP3A4 and CYP3A5 polymorphisms were significantly associated with an increased risk of prostate cancer

Candidate gene
Marker	combination of CYP3A4 and CYP3A5 may serve as a novel prognostic biomarker in lung adenocarcinoma, which contribute to the precision of predicting the survival in lung adenocarcinoma
Therapy target

ANIMAL & CELL MODELS