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FLASH GENE
Symbol CYP3A4 contributors: mct - updated : 05-04-2019
HGNC name cytochrome P450, family 3, subfamily A, polypeptide 4
HGNC id 2637
ASSOCIATED DISORDERS
corresponding disease(s)
related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in lung cancer
constitutional       loss of function
marked reduction of CYP3A4 activity among individuals with Crohn disease
Susceptibility
  • to prostate cancer
  • to treatment-related leukemia
  • Variant & Polymorphism other
  • polymorphism CYP3A4V potentially increased susceptibility to prostate cancer
  • CYP3A4-W genotype may be at increased risk for treatment-related leukemia
  • CYP3A4-W genotype may increase production of potentially DNA-damaging reactive intermediates and may decrease production of the epipodophyllotoxin catechol metabolite, which is the precursor of the potentially DNA-damaging quinone
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS