Symbol
| CYP3A4
| contributors: mct - updated : 05-04-2019
|
HGNC name
| cytochrome P450, family 3, subfamily A, polypeptide 4
|
HGNC id
| 2637
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
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tumoral
|  
|  
| --low
|  
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in lung cancer | constitutional
|  
|  
|  
| loss of function
|
marked reduction of CYP3A4 activity among individuals with Crohn disease | |
Susceptibility
|
to prostate cancer to treatment-related leukemia |
Variant & Polymorphism
other
| polymorphism CYP3A4V potentially increased susceptibility to prostate cancer |
|
CYP3A4-W genotype may be at increased risk for treatment-related leukemia |
|
CYP3A4-W genotype may increase production of potentially DNA-damaging reactive intermediates and may decrease production of the epipodophyllotoxin catechol metabolite, which is the precursor of the potentially DNA-damaging quinone |
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Candidate gene
Marker
Therapy target
| | | |