protein
| flavoprotein P450 oxidoreductase (POR) |
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transcriptional target of SMARCA4 |
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NR1I2 promoter methylation is involved in the regulation of intestinal NR1I2 and CYP3A4 mRNA expression and might be associated with the inter-individual variability of the drug responses of colon cancer cells |
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PPARA is a direct transcriptional regulator of hepatic CYP3A4 |
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RXRA mediates the sex-dependent influence of GH on CYP3A expression as an important signalling molecule |
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CYP3A4 activates, rather than inactivates, 20(OH)D3 |
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steroid hormones are likely able to regulate CYP3A4 mRNA expression, although the circulating levels of these hormones can only regulate control endometrium and not endometriosis tissues |
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cross-talk between NR1I2 and AHR plays a role in the regulation of CYP3A4 gene expression |
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NR1I2 plays a central role in cortisol-mediated induction of CYP3A4 activity during pregnancy |