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FLASH GENE
Symbol RLN1 contributors: mct/npt - updated : 13-10-2009
HGNC name relaxin 1
HGNC id 10026
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a B-chain
  • a connecting C-peptide
  • an A-chain, forming a mature dipeptide (A,B) chains linked by sisulfide bond
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to RLN2
    Homologene
    FAMILY
  • insulin family
    • CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • physiological changes leading to parturition
  • acting with estrogen to produce dilatation of the birth canal in many mammals and may be involved in remodeling of connective tissues during pregnancy
  • function beyond its ability to regulate collagen turnover(Samuel 2007)
  • plays an important role in the regulation of airway structure and function (Samuel 2007)
  • relaxin signaling plays a role in prostate cancer progression (Feng 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endothelin B (antagonist of)
    • cell & other
    REGULATION
    Other regulated by progesterone receptor (PR)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate adenocarcinoma
    constitutional     --over  
    increased decidual RLN expression may induce a local sterile inflammatory process which potentially contributes to extracellular matrix degradation and weakening of the fetal membranes (Bryant-Greenwood 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS