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FLASH GENE

Symbol

MET

contributors: mct/shn - updated : 28-10-2018

HGNC name	met proto-oncogene (hepatocyte growth factor receptor)
HGNC id	7029

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HPRC , AUTS9 , OSFD , DFNB97

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation   --over   in sporadic PRC tumoral   amplification     amplified in glioblastomas tumoral somatic mutation       in childhood hepatocellular carcinomas tumoral     --over   with LRRK2 in papillary renal cell carcinoma, and in papillary thyroid carcinoma tumoral   amplification     highly selective and commonly occurs in clear-cell adenocarcinoma tumoral somatic mutation     gain of function MET activating mutations are genetic markers associated with the cancers of unknown primary origin (CUPs)

Susceptibility

to autism

Variant & Polymorphism other	CC genotype increasing the risk of autism (C allele results in a 2-fold decrease in MET promoter activity and altered binding of specific transcription factor complexes)

Candidate gene
Marker	could serve as a biomarker for the prognostication of patients with clear-cell adenocarcinoma and tumor progression
Therapy target
	System Type Disorder Pubmed cancer head and neck   dual blockade of MET and EGFR may be a promising clinical therapeutic strategy for treating HNSCC cancer reproductive ovary novel therapeutic target for ovarian clear-cell carcinoma cancer reproductive prostate c-Met inhibitors demonstrated anti-proliferative efficacy when combined with androgen ablation therapy for advanced prostate cancer

ANIMAL & CELL MODELS

Mutation of Met tyrosine kinase in the mouse genome caused embryonal death, with placenta, liver, and limb muscle defects