| Symbol
| HPRC
|
| Location
| 7q31.2
|
| Name
|
hereditary papillary renal carcinoma |
| Corresponding gene
|
MET
|
| Main clinical features
|
predisposition to multiple, bilateral papillary renal tumors, type 1 histology |
| Genetic determination
| autosomal dominant |
| Prevalence
| rare, most cases are sporadic
|
| Related entries
| HLRCC
|
| Function/system disorder
| kidney and urinary tract |
|
| neoplasia |
| Type
| malignancy
|
| Name
| MET tyrosine kinase receptor for hepatocyte growth factor/scatter factor
|
| Gene mutation | Chromosome rearrangement | Effect | Comments |
|
|---|
| missense
|
| over-expression
| germinal activating missense mutations in the tyrosine kinase domain of the MET proto-oncogene
| |
| aneuploidy
|
| in tumors, acquired trisomy/tetrasomy most often including chr 7 and 17 and loss of chr Y
| |
| Remark(s)
|
constitutive activation of the MET receptor function |