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FLASH GENE
Symbol INHBA contributors: - updated : 23-09-2004
HGNC name inhibin, beta A (activin A, activin AB alpha polypeptide)
HGNC id 6066
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , heteromer , dimer
isoforms Precursor
HOMOLOGY
interspecies ortholog to murine Inhba
homolog to C.elegans B0412.2
Homologene
FAMILY
  • TGFB superfamily member
  • BMP family
    • CATEGORY signaling hormone growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inhibiting secretion of pituitary follicle-stimulating hormone
  • involved in embryonic axis development
  • regulating negatively gonadal stromal cell proliferation
  • having tumour-suppressor activity
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • erythroid
  • skeletal development
    • PATHWAY
    metabolism
    signaling hormonal
    FSH releasing protein
    a component
  • homodimerizing to form activin A stimulator of FSH secretion and involved in embryonic axis development
  • heterodimerizing with INHBB or INHA to form activin AB or inhibin A,respectively
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice Inhba -/- demonstrate dysruption of whisker,palate,tooth development