| basic FUNCTION
| adipokine playing an essential role in the final differentiation of B-cells into Ig-secreting cells, inducing myeloma and plasmacytoma growth, also inducing nerve cells differentiation, in hepatocytes it induces acute phase reactants |
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B cell stimulating factor 2, involved in the regulation of immune response, hematopoiesis, platelets production |
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playing a role in the aggressiveness of non Hodgkin lymphoma by stimulating MMP2 and MMP9 |
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involved in protecting retinal ganglion cells from pressure-induced death |
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triggering VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP9 overexpression |
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initiates the expression of RAG1 and RAG2 in circulating B cells, and extends those in tonsil B cells  |
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dual role of IL6 in inducing and terminating expression of the recombinase machinery for secondary rearrangements in mature human B cells |
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may be involved in pathophysiology of unexplained infertility |
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involved in early control of the virus, limiting activation of the adaptive immune response and preventing death of the HBV-infected hepatocyte |
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with LIF, LEP, CNTF, participate to the complex control of the reproductive function by affecting the development and function of the hypothalamus-pituitary system at different ontogenic times and anatomical sites |
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increases TJ (tight junction) permeability by stimulating the expression of CLDN2, which is required for increased CDX2 through the MEK/ERK and PI3K pathways in intestinal epithelial cells |
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implicated in the regulation of insulin secretion |
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SRC and IL6 inhibit osteoblast differentiation and integrate IGFBP5 signalling |
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IL6 produced locally by resident brain cells promotes post-stroke angiogenesis and thereby affords long-term histological and functional protection |
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mesenchymal stem cells (MSCs)-secreted IL6 and VEGFA may act as paracrine factors to sustain breast cancer cell migration |
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is now known to participate in neurogenesis (influencing both neurons and glial cells), and in the response of mature neurons and glial cells in normal conditions |
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importance of IL6 mediated stromal-epithelial cell interaction in gastric tumorigenesis. (pMID: 23593346) |
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is a T cell homeostatic cytokine that expands T cell space and can maintain the na |
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ve T cell pool |
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causes compromised tissue repair by shifting acute inflammation into a more chronic profibrotic state through induction of Th1 cell responses as a consequence of recurrent inflammation |
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IL6 is potentially increased as a result of adipose deposition and CD4(+) cell inflammation in lymphedema |
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signaling via IL6 as an important determinant of the alternative activation of macrophages and assign an unexpected homeostatic role to IL6 in limiting inflammation |
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modulates the expression of SOX2, resulting in decreased multipotency and causing primitive multipotent cells to undergo osteogenic lineage commitment |
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plays an important role in the development and progression of inflammatory responses, autoimmune diseases, and cancers |
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IL6 together with IL17A synergistically enhances the expression of survival molecules to hinder critical host defense mechanisms removing virus-infected cells |
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signalling pathways activated by IL6 have a crucial role in the regulation of CDX2 that is a key factor in the process of gastric carcinogenesis |
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IL6, JUN, and PLAU may be involved in development of neuropathic pain |
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is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells, including hepatocytes |
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IL8, IL6, IL5 might likely play central roles in cytokine storms associated with COVID-19 |
