| 1 | IL6, MARCHF3, STAT3
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| The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis.
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| Lin H, Feng L, Cui KS, Zeng LW, Gao D, Zhang LX, Xu WH, Sun YH, Shu HB, Li S.
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| Cell Mol Immunol. Dec;18(12):2648-2659. doi: 10.1038/s41423-021-00799-1. Epub 2021 Nov 16. 2021
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| 2 | IL5, IL6, IL8
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| An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis
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| Liu Y, Chen D, Hou J, Li H, Cao D, Guo M, Ling Y, Gao M, Zhou Y, Wan Y, Zhu Z.
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| Cytokine. Feb;138:155365. doi: 10.1016/j.cyto.2020.155365. Epub 2020 Nov 9. 2021
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| 3 | IFNA1, IL6, SOCS3
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| Induction of interleukin 6 impairs the anti-HBV efficiency of IFN-α in human hepatocytes through upregulation of SOCS3.
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| Yang K, Guan S, Zhang H, Chen Z.
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| J Med Virol 91(5):803-812. doi: 10.1002/jmv.25382. Epub 2019 Jan 2.
2019
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| 4 | IL6, TCF21
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| Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells.
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| Akama T, Chun TH.
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| J Biol Chem. Apr 27;293(17):6603-6610. doi: 10.1074/jbc.RA117.000456. Epub 2018 Mar 14 2018
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| 5 | IL6, JUN, PLAU
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| Identification of the key genes associated with neuropathic pain
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| Liu H, Xia T, Xu F, Ma Z, Gu X.
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| Mol Med Rep. May;17(5):6371-6378. doi: 10.3892/mmr.2018.8718. Epub 2018 Mar 9. 2018
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| 6 | IL21, IL6
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| IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.
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| Yang R, Masters AR, Fortner KA, Champagne DP, Yanguas-Casás N, Silberger DJ, Weaver CT, Haynes L, Rincon M.
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| J Exp Med 213(11):2281-2291. Epub 2016 Sep 26.
2016
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| 7 | IL6
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| Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife.
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| Singh-Manoux A, Dugravot A, Brunner E, Kumari M, Shipley M, Elbaz A, Kivimaki M.
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| Neurology 83(6):486-93. doi: 10.1212/WNL.0000000000000665. Epub 2014 Jul 2.
2014
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| 8 | CDX2, IL6
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| CDX2 can be regulated through the signalling pathways activated by IL-6 in gastric cells.
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| Cobler L, Pera M, Garrido M, Iglesias M, de Bolós C.
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| Biochim Biophys Acta 1839(9):785-92. doi: 10.1016/j.bbagrm.2014.06.009. Epub 2014 Jun 19.
2014
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| 9 | IL6, SOX2
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| Interleukin-6 induces the lineage commitment of bone marrow-derived mesenchymal multipotent cells through down-regulation of Sox2 by osteogenic transcription factors.
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| Yoon DS, Kim YH, Lee S, Lee KM, Park KH, Jang Y, Lee JW.
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| FASEB J 28(7):3273-86. doi: 10.1096/fj.13-248567. Epub 2014 Apr 9.
2014
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| 10 | IL6
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| Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.
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| Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC.
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| Nat Immunol 15(5):423-30. doi: 10.1038/ni.2865. Epub 2014 Mar 30.
2014
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| 11 | IL6
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| IL-6 regulates adipose deposition and homeostasis in lymphedema.
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| Cuzzone DA, Weitman ES, Albano NJ, Ghanta S, Savetsky IL, Gardenier JC, Joseph WJ, Torrisi JS, Bromberg JF, Olszewski WL, Rockson SG, Mehrara BJ.
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| Am J Physiol Heart Circ Physiol 306(10):H1426-34. doi: 10.1152/ajpheart.01019.2013. Epub 2014 Mar 14.
2014
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| 12 | DAXX, IL6
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| Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages.
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| Yao Z, Zhang Q, Li X, Zhao D, Liu Y, Zhao K, Liu Y, Wang C, Jiang M, Li N, Cao X.
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| J Biol Chem 289(13):9372-9. doi: 10.1074/jbc.M113.533992. Epub 2014 Feb 18.
2014
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| 13 | IL6
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| Interleukin-6 signaling drives fibrosis in unresolved inflammation.
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| Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA.
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| Immunity 40(1):40-50. doi: 10.1016/j.immuni.2013.10.022. Epub 2014 Jan 9.
2014
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| 14 | CD80, CD86, IL6
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| Novel regulation of CD80/CD86-induced phosphatidylinositol 3-kinase signaling by NOTCH1 protein in interleukin-6 and indoleamine 2,3-dioxygenase production by dendritic cells.
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| Koorella C, Nair JR, Murray ME, Carlson LM, Watkins SK, Lee KP.
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| J Biol Chem 289(11):7747-62. doi: 10.1074/jbc.M113.519686. Epub 2014 Jan 10.
2014
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| 15 | CEBPB, IL6, TMUB1
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| CCAAT/enhancer-binding protein β regulates interleukin-6-induced transmembrane and ubiquitin-like domain containing 1 gene expression in hepatocytes
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| Liu M, Yuan T, Liu H, Chen P
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| Mol Med Rep Oct;10(4):2177-83. doi: 10.3892/mmr.2014.2457. Epub 2014 Aug 6. 2014
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| 16 | IL6, RBM8A
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| Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.
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| Togi S, Shiga K, Muromoto R, Kato M, Souma Y, Sekine Y, Kon S, Oritani K, Matsuda T.
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| J Immunol 191(3):1436-44. doi: 10.4049/jimmunol.1300501. Epub 2013 Jul 1.
2013
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| 17 | EGFR, IL6, SOCS3, STAT3
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| STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.
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| Wang Y, van Boxel-Dezaire AH, Cheon H, Yang J, Stark GR.
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| Proc Natl Acad Sci U S A 110(42):16975-80. doi: 10.1073/pnas.1315862110. Epub 2013 Sep 30.
2013
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| 18 | IL1RL1, IL33, IL6, IL8, TMED1
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| The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.
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| Connolly DJ, O'Neill LA, McGettrick AF.
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| J Biol Chem 288(8):5616-23. doi: 10.1074/jbc.M112.403899. Epub 2013 Jan 14.
2013
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| 19 | IL6
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| Cerebrospinal fluid interleukin-6 in central nervous system inflammatory diseases.
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| Wullschleger A, Kapina V, Molnarfi N, Courvoisier DS, Seebach JD, Santiago-Raber ML, Hochstrasser DF, Lalive PH.
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| PLoS One 8(8):e72399. doi: 10.1371/journal.pone.0072399. eCollection 2013.
2013
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| 20 | IL6
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| Interleukin-6 expands homeostatic space for peripheral T cells.
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| Hong C, Nam AS, Keller HR, Ligons DL, Park JY, Yoon HW, Park JJ, Luckey MA, Park JH.
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| Cytokine 64(2):532-40. doi: 10.1016/j.cyto.2013.08.001. Epub 2013 Aug 26.
2013
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| 21 | ACAN, IL6, MMP13
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| Interleukin 6 mediates selected effects of Notch in chondrocytes.
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| Zanotti S, Canalis E.
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| Osteoarthritis Cartilage 21(11):1766-73. doi: 10.1016/j.joca.2013.08.010. Epub 2013 Aug 14.
2013
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| 22 | IL6, KLF4
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| KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification.
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| Rosenzweig JM, Glenn JD, Calabresi PA, Whartenby KA.
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| J Biol Chem 288(33):23868-74. doi: 10.1074/jbc.M113.479576. Epub 2013 Jul 11.
2013
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| 23 | IL6
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| Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.
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| Kinoshita H, Hirata Y, Nakagawa H, Sakamoto K, Hayakawa Y, Takahashi R, Nakata W, Sakitani K, Serizawa T, Hikiba Y, Akanuma M, Shibata W, Maeda S, Koike K.
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| PLoS One 8(4):e60914. doi: 10.1371/journal.pone.0060914. Print 2013.
2013
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| 24 | IL6
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| Relevance of IL-6 and MMP-9 to cerebral arteriovenous malformation and hemorrhage.
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| Li X, Wang R, Wang X, Xue X, Ran D, Wang S.
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| Mol Med Rep 7(4):1261-6. doi: 10.3892/mmr.2013.1332. Epub 2013 Feb 20.
2013
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| 25 | BTG2, IL6, sTAT3
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| TIS21(/BTG2/PC3) inhibits interleukin-6 expression via downregulation of STAT3 pathway.
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| Quy LN, Choi YW, Kim YH, Chwae YJ, Park TJ, Lim IK.
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| Cell Signal 25(12):2391-9. doi: 10.1016/j.cellsig.2013.07.024.
2013
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| 26 | IGFBP5, IL6, SRC
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| c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling.
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| Peruzzi B, Cappariello A, Del Fattore A, Rucci N, De Benedetti F, Teti A.
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| Nat Commun 3:630. doi: 10.1038/ncomms1651.
2012
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| 27 | IL6
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| Interleukin-6, a major cytokine in the central nervous system.
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| Erta M, Quintana A, Hidalgo J.
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| Int J Biol Sci 8(9):1254-66. doi: 10.7150/ijbs.4679. Epub 2012 Oct 25. Review.
2012
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| 28 | GREB1, IL6, STAT3
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| GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer.
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| Liu M, Wang G, Gomez-Fernandez CR, Guo S.
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| PLoS One 7(10):e46410. doi: 10.1371/journal.pone.0046410. Epub 2012 Oct 3. 2012
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| 29 | IL6, VEGFA
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| Mesenchymal stem cell-derived interleukin-6 and vascular endothelial growth factor promote breast cancer cell migration.
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| De Luca A, Lamura L, Gallo M, Maffia V, Normanno N.
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| J Cell Biochem 113(11):3363-70. doi: 10.1002/jcb.24212.
2012
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| 30 | IL6
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| Essential role of interleukin-6 in post-stroke angiogenesis.
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| Gertz K, Kronenberg G, Kälin RE, Baldinger T, Werner C, Balkaya M, Eom GD, Hellmann-Regen J, Kröber J, Miller KR, Lindauer U, Laufs U, Dirnagl U, Heppner FL, Endres M.
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| Brain 135(Pt 6):1964-80. doi: 10.1093/brain/aws075. Epub 2012 Apr 3.
2012
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| 31 | IL6, STAT5A
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| IL-6 activates STAT5 in T cells.
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| Tormo AJ, Letellier MC, Sharma M, Elson G, Crabé S, Gauchat JF.
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| Cytokine 60(2):575-82. doi: 10.1016/j.cyto.2012.07.002. Epub 2012 Jul 31.
2012
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| 32 | IL6, NFKB1, STAT3
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| NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells.
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| Yoon S, Woo SU, Kang JH, Kim K, Shin HJ, Gwak HS, Park S, Chwae YJ.
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| Oncogene ncogene. 2012 2012
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| 33 | CCL2, EDN1, IL6
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| Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
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| Simonson MS, Ismail-Beigi F.
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| J Biol Chem 286(13):11003-8. Epub 2010 Dec 17.
2011
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| 34 | CXCL12, CXCR4, IL6
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| Stromal cell-derived factor-1/CXCR4 promotes IL-6 production in human synovial fibroblasts.
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| Chen HT, Tsou HK, Hsu CJ, Tsai CH, Kao CH, Fong YC, Tang CH.
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| J Cell Biochem 112(4):1219-27. doi: 10.1002/jcb.23043.
2011
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| 35 | IL6
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| Inhibition of IL6 in rheumatoid arthritis and juvenile idiopathic arthritis.
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| Mircic M, Kavanaugh A.
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| Exp Cell Res 317(9):1286-92. Epub 2011 Mar 22. Review.
2011
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| 36 | CDH11, IL6
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| Cadherin-11 regulates fibroblast inflammation.
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| Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB.
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| Proc Natl Acad Sci U S A 108(20):8402-7. Epub 2011 May 2.
2011
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| 37 | CCL5, GLI2, IL6
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| GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.
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| Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME.
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| J Biol Chem 286(24):21524-34. Epub 2011 Mar 18.
2011
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| 38 | CDX2, CLDN2, IL6
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| Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium.
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| Suzuki T, Yoshinaga N, Tanabe S.
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| J Biol Chem 286(36):31263-71. Epub 2011 Jul 19. 2011
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| 39 | CSNK2A1, IL6
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| Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer.
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| Drygin D, Ho CB, Omori M, Bliesath J, Proffitt C, Rice R, Siddiqui-Jain A, O'Brien S, Padgett C, Lim JK, Anderes K, Rice WG, Ryckman D.
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| Biochem Biophys Res Commun 415(1):163-7. doi: 10.1016/j.bbrc.2011.10.046. Epub 2011 Oct 18.
2011
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| 40 | IL6, MMP13
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| IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells.
|
| Tang CH, Chen CF, Chen WM, Fong YC.
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| J Biol Chem 286(13):11056-66. doi: 10.1074/jbc.M110.204081. Epub 2011 Jan 28.
2011
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| 41 | IL6
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| Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.
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| Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, Eppler E, Bouzakri K, Wueest S, Muller YD, Hansen AM, Reinecke M, Konrad D, Gassmann M, Reimann F, Halban PA, Gromada J, Drucker DJ, Gribble FM, Ehses JA, Donath MY.
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| Nat Med 17(11):1481-9. doi: 10.1038/nm.2513.
2011
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| 42 | IL6, RAB7B
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| Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association
|
| He D, Chen T, Yang M, Zhu X, Wang C, Cao X, Cai Z.
|
| J Mol Med (Berl). Feb;89(2):137-50. doi: 10.1007/s00109-010-0689-z. Epub 2010 Oct 16. 2011
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| 43 | IL6, OSM, S100A7
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| S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer.
|
| West NR, Watson PH.
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| Oncogene 29(14):2083-92. Epub 2010 Jan 18.PMID: 20101226 2010
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| 44 | IL6, LEP, STEAP4, TNF
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| STEAP4, a gene associated with insulin sensitivity, is regulated by several adipokines in human adipocytes.
|
| Chen X, Zhu C, Ji C, Zhao Y, Zhang C, Chen F, Gao C, Zhu J, Qian L, Guo X.
|
| Int J Mol Med 25(3):361-7.
2010
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| 45 | IL6
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| Serum IL-6 level may have role in the pathophysiology of unexplained infertility.
|
| Demir B, Guven S, Guven ES, Atamer Y, Gul T.
|
| Am J Reprod Immunol 62(4):261-7. Epub 2009 Aug 24.PMID: 19706022 2009
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| 46 | IL6
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| Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease.
|
| He MX, Yang WL, Zhang MM, Lian YJ, Hua HY, Zeng JS, Zhang LR.
|
| Neurol Sci eurol Sci. 2009 Dec 3. [Epub ahead of print]PMID: 19957198 2009
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| 47 | IL6
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| Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants.
|
| Wu YW, Croen LA, Torres AR, Van De Water J, Grether JK, Hsu NN.
|
| Ann Neurol 66(5):663-70.PMID: 19938160 2009
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| 48 | IL6
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| Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease.
|
| Capurso C, Solfrizzi V, Colacicco AM, D'Introno A, Frisardi V, Imbimbo BP, Lorusso M, Vendemiale G, Denitto M, Santamato A, Seripa D, Pilotto A, Fiore P, Capurso A, Panza F.
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| Prog Neuropsychopharmacol Biol Psychiatry rog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 6. [Epub ahead of print]PMID: 19897004 2009
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| 49 | ATM, IL6
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| Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
|
| Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J.
|
| Nat Cell Biol 11(8):973-9. Epub 2009 Jul 13. Erratum in: Nat Cell Biol. 2009 Oct;11(10):1272. Dosage error in article text. PMID: 19597488 2009
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| 50 | IL6
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| Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
|
| Hösel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, Broxtermann M, Tedjokusumo R, Esser K, Arzberger S, Kirschning CJ, Langenkamp A, Falk C, Büning H, Rose-John S, Protzer U.
|
| Hepatology 50(6):1773-82.PMID: 19937696 2009
|
| 51 | CNTF, IL6, LEP, LIF
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| Leptin, ciliary neurotrophic factor, leukemia inhibitory factor and interleukin-6: class-I cytokines involved in the neuroendocrine regulation of the reproductive function.
|
| Dozio E, Ruscica M, Galliera E, Corsi MM, Magni P.
|
| Curr Protein Pept Sci 10(6):577-84. Review.PMID: 19751193 2009
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| 52 | IL6, IL6ST
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| A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
|
| Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Müller W, Kuner R, Davis JB, Rose-John S, Kress M.
|
| J Neurosci 29(43):13473-83.PMID: 19864560 2009
|
| 53 | IL1A, IL1B, IL6, TNF
|
| Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.
|
| Turner NA, Das A, Warburton P, O'Regan DJ, Ball SG, Porter KE.
|
| Am J Physiol Heart Circ Physiol 297(3):H1117-27. doi: 10.1152/ajpheart.00372.2009. Epub 2009 Jul 31.
2009
|
| 54 | ENTPD2, IL6
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| IL-6 downregulates transcription of NTPDase2 via specific promoter elements.
|
| Yu J, Lavoie EG, Sheung N, Tremblay JJ, Sévigny J, Dranoff JA.
|
| Am J Physiol Gastrointest Liver Physiol 294(3):G748-56. doi: 10.1152/ajpgi.00208.2007. Epub 2008 Jan 17.
2008
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| 55 | IL1B, IL10, IL6, TGFB1
|
| [Genetic markers of predisposition to an aggressive course of chronic C hepatitis]
|
| Abdullaev SM, Tselishcheva IuI, Samokhodskaia LM, Kvasovka VV, Ignatova TM, Krasnova TN, Bochkov VN, Mukhin NA.
|
| Vestn Ross Akad Med Nauk (1):8-13. Russian. 2007
|
| 56 | IL1B, IL6
|
| Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.
|
| Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C.
|
| Gastroenterology 132(1):154-65. Epub 2006 Oct 12. 2007
|
| 57 | CSF2, IL1A, IL12B, IL15, IL17A, IL18, IL23A, IL6
|
| Cytokines in the pathogenesis of rheumatoid arthritis.
|
| McInnes IB, Schett G.
|
| Nat Rev Immunol 7(6):429-42. Review. 2007
|
| 58 | ADIPOR1, IL6
|
| Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway.
|
| Tang CH, Chiu YC, Tan TW, Yang RS, Fu WM.
|
| J Immunol 179(8):5483-92. 2007
|
| 59 | IL6, PRKAA1
|
| Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms.
|
| Weigert C, Düfer M, Simon P, Debre E, Runge H, Brodbeck K, Häring HU, Schleicher ED.
|
| Am J Physiol Cell Physiol 293(3):C1139-47. Epub 2007 Jul 5. 2007
|
| 60 | IL6, RAG1, RAG2
|
| IL-6 contributes to the expression of RAGs in human mature B cells.
|
| Hillion S, Dueymes M, Youinou P, Jamin C.
|
| J Immunol 179(10):6790-8.
2007
|
| 61 | ATF3, TLR4, IL6, IL12B
|
| Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
|
| Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Kennedy K, Hai T, Bolouri H, Aderem A.
|
| Nature 441(7090):173-8. 2006
|
| 62 | IL6, BCL2, ADCYAP1
|
| Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.
|
| Ohtaki H, Nakamachi T, Dohi K, Aizawa Y, Takaki A, Hodoyama K, Yofu S, Hashimoto H, Shintani N, Baba A, Kopf M, Iwakura Y, Matsuda K, Arimura A, Shioda S.
|
| Proc Natl Acad Sci U S A 103(19):7488-93. Epub 2006 May 1. 2006
|
| 63 | IL6
|
| Interleukin-6 and the risk of future cardiovascular events in patients with angina pectoris and/or healed myocardial infarction.
|
| Fisman EZ, Benderly M, Esper RJ, Behar S, Boyko V, Adler Y, Tanne D, Matas Z, Tenenbaum A.
|
| Am J Cardiol 98(1):14-8. Epub 2006 Apr 27. 2006
|
| 64 | IL6
|
| Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis.
|
| Qi L, van Dam RM, Meigs JB, Manson JE, Hunter D, Hu FB.
|
| Hum Mol Genet 15(11):1914-20. Epub 2006 Apr 27. 2006
|
| 65 | IL6
|
| Interleukin-6 protects retinal ganglion cells from pressure-induced death.
|
| Sappington RM, Chan M, Calkins DJ.
|
| Invest Ophthalmol Vis Sci 47(7):2932-42. 2006
|
| 66 | IL6
|
| A protective role for IL-6 in staphylococcal microbial keratitis.
|
| Hume EB, Cole N, Garthwaite LL, Khan S, Willcox MD.
|
| Invest Ophthalmol Vis Sci 47(11):4926-30. 2006
|
| 67 | KDR, IL6, MMP9
|
| Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: the role for KDR and MMP-9.
|
| Yao JS, Zhai W, Young WL, Yang GY.
|
| Biochem Biophys Res Commun 342(4):1396-404. Epub 2006 Feb 28. 2006
|
| 68 | TNFRSF1B, IL6
|
| Association tests of interleukin-6 (IL-6) and type II tumor necrosis factor receptor (TNFR2) genes with bone mineral density in Caucasians using a re-sampling approach.
|
| Xiao P, Liu PY, Lu Y, Guo YF, Xiong DH, Li LH, Recker RR, Deng HW.
|
| Hum Genet 117(4):340-8. Epub 2005 May 20. 2005
|
| 69 | IL6, TS, CRP
|
| Adipokine dysregulation in turner syndrome: comparison of circulating interleukin-6 and leptin concentrations with measures of adiposity and C-reactive protein.
|
| Ostberg JE, Attar MJ, Mohamed-Ali V, Conway GS.
|
| J Clin Endocrinol Metab 90(5):2948-53. Epub 2005 Feb 22. 2005
|
| 70 | IL6, NFKBIZ
|
| Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
|
| Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.
|
| Nature 430(6996):218-22. 2004
|
| 71 | IL6
|
| The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians.
|
| Vozarova B, Fernandez-Real JM, Knowler WC, Gallart L, Hanson RL, Gruber JD, Ricart W, Vendrell J, Richart C, Tataranni PA, Wolford JK.
|
| Hum Genet 112(4):409-13. Epub 2003 Feb 14. 2003
|
| 72 | CST2, IL6
|
| Salivary cystatins induce interleukin-6 expression via cell surface molecules in human gingival fibroblasts.
|
| Kato T, Imatani T, Minaguchi K, Saitoh E, Okuda K.
|
| Mol Immunol 39(7-8):423-30. 2002
|
| 73 | IL6
|
| Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells.
|
| Conze D, Weiss L, Regen PS, Bhushan A, Weaver D, Johnson P, Rincon M.
|
| Cancer Res 61(24):8851-8. 2001
|
| 74 | IL6
|
| Interleukine-6 (IL-6) synthesis and gp130 expression by human pericardium.
|
| Menet E, Corbi P, Ancey C, Morel F, Delwail A, Garcia M, Osta AM, Wijdenes J, Potreau D, Lecron JC.
|
| Eur Cytokine Netw 12(4):639-46. 2001
|
| 75 | IL6
|
| IL-6 gene amplification and expression in human glioblastomas.
|
| Tchirkov A, Rolhion C, Bertrand S, Dore JF, Dubost JJ, Verrelle P.
|
| Br J Cancer 85(4):518-22. 2001
|
| 76 | IL6, MMP3
|
| Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis.
|
| Rauramaa R, Vaisanen SB, Luong LA, Schmidt-Trucksass A, Penttila IM, Bouchard C, Toyry J, Humphries SE.
|
| Arterioscler Thromb Vasc Biol 20(12):2657-62. 2000
|
| 77 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
|
| Sequence diversity in 36 candidate genes for cardiovascular disorders.
|
| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
|
| Am J Hum Genet 65(1):183-91. 1999
|
| 78 | IL6, MMP9, TIMP1
|
| Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas.
|
| Kossakowska AE, Edwards DR, Prusinkiewicz C, Zhang MC, Guo D, Urbanski SJ, Grogan T, Marquez LA, Janowska-Wieczorek A.
|
| Blood 94(6):2080-9 1999
|
| 79 | IL6
|
| Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis.
|
| Ota N, Hunt SC, Nakajima T, Suzuki T, Hosoi T, Orimo H, Shirai Y, Emi M.
|
| Hum Genet 105(3):253-7. 1999
|
| 80 | IL6
|
| Sequence similarity between NKSF and the IL-6/G-CSF family.
|
| Merberg DM, Wolf SF, Clark SC.
|
| Immunol Today 13(2):77-8. 1992
|
| 81 | IL6, IL1B, TNF
|
| Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease.
|
| Stevens C, Walz G, Singaram C, Lipman ML, Zanker B, Muggia A, Antonioli D, Peppercorn MA, Strom TB.
|
| Dig Dis Sci 37(6):818-26. 1992
|
| 82 | IL1A, IL6, IL8, TNFRSF1A
|
| Heterogeneity among human nasopharyngeal carcinoma cell lines for inflammatory cytokines mRNA expression levels.
|
| Mahe Y, Hirose K, Clausse B, Chouaib S, Tursz T, Mariame B.
|
| Biochem Biophys Res Commun 187(1):121-6. 1992
|
| 83 | IL6
|
| Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone.
|
| Ohsaki Y, Takahashi S, Scarcez T, Demulder A, Nishihara T, Williams R, Roodman GD.
|
| Endocrinology 131(5):2229-34. 1992
|
| 84 | IL6
|
| BglII polymorphism in the human interleukin 6 (IL 6) gene.
|
| Fugger L, Morling N, Bendtzen K, Ryder LP, Svejgaard A.
|
| Nucleic Acids Res 17(18):7548 1989
|
| 85 | IL6
|
| Rapid detection and sequencing of alleles in the 3' flanking region of the interleukin-6 gene.
|
| Bowcock AM, Ray A, Erlich H, Sehgal PB.
|
| Nucleic Acids Res 17(17):6855-64. 1989
|
| 86 | IL4, IL6
|
| Interleukin 4 is at 5q31 and interleukin 6 is at 7p15.
|
| Sutherland GR, Baker E, Callen DF, Hyland VJ, Wong G, Clark S, Jones SS, Eglinton LK, Shannon MF, Lopez AF, et al.
|
| Hum Genet 79(4):335-7 1988
|
| 87 | IL6
|
| Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21.
|
| Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB, Ruddle FH.
|
| Genomics 2(3):203-8. 1988
|
| 88 | IL6
|
| The human interferon-beta-2/hepatocyte stimulating factor/interleukin-6 gene : DNA polymorphism studies and localization to chromosome 7p21.
|
| Bowcock AM, Kidd JR, Lathrop GM, Daneshvar L, May LT, Ray A, Sehgal PB, Kidd KK, Cavalli-Sforza LL.
|
| Genomics 3(1):8-16. 1988
|
| 89 | IL6
|
| RFLPs revealed by beta-2 interferon and their population distribution.
|
| Bowcock AM, et al.
|
| (HGM9) Cytogenet Cell Genet 46 : 585. 1987
|
| 90 | IL6
|
| Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical.
|
| Sehgal PB, May LT, Tamm I, Vilcek J.
|
| Science 235(4790):731-2. 1987
|
| 91 | IL6
|
| Regional localization of the human B2-interferon gene.
|
| Chen Y, et al.
|
| Am J Hum Genet 41 : A161. 1987
|
| 92 | IL6
|
| Human chromosome 7 carries the beta-2 interferon gene.
|
| Sehgal PB, Zilberstein A, Ruggieri RM, May LT, Ferguson-Smith A, Slate DL, Revel M, Ruddle FH.
|
| Proc Natl Acad Sci U S A 83(14):5219-22. 1986
|
| 93 | IFNB1, IL6, IFNB3
|
| Multiple human beta interferon genes.
|
| Sagar AD, Sehgal PB, Slate DL, Ruddle FH.
|
| J Exp Med 156(3):744-55. 1982
|