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FLASH GENE
Symbol EIF4H contributors: mct - updated : 04-05-2020
HGNC name eukaryotic translation initiation factor 4H
HGNC id 12741
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motifs
  • a C terminal transmembrane region
    • HOMOLOGY
    interspecies homolog to murine Wbscr1
    intraspecies homolog to RNA-binding proteins
    Homologene
    FAMILY
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    basic FUNCTION
  • translation factor, stimulating the initiation of protein synthesis at the mRNA level
  • with EIF4B contribute to RNA affinity of the complex through weak interactions not detectable in structural assays (Rozovsky 2008)
  • plays a crucial role in translational control and can promote cellular transformation by preferentially regulating the translation of potent growth and survival factor mRNAs
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of eIF4A/4G/4H helicase complex (Marintchev 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EIF4A
  • EIF4B
  • EIF4H is much less efficient at stimulating EIF4A unwinding activity than EIF4B, implying that EIF4H is not able to completely substitute for EIF4B in duplex unwinding
  • RELA p65-dependent transcriptional activation of EIF4H increased the EIF4H protein content augmenting the rate of global protein synthesis
  • DROSHA can cleave the alternatively spliced exon 5 of the EIF4H gene
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WBS
    Susceptibility
    Variant & Polymorphism other base-pair inversion polymorphism predisposing to primarily WBS- causing microdeletions
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a promising new molecular target for cancer therapy
    ANIMAL & CELL MODELS