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FLASH GENE
Symbol EIF4H contributors: mct - updated : 04-05-2020
HGNC name eukaryotic translation initiation factor 4H
HGNC id 12741
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RNA recognition motifs
  • a C terminal transmembrane region
  • HOMOLOGY
    interspecies homolog to murine Wbscr1
    intraspecies homolog to RNA-binding proteins
    Homologene
    FAMILY
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    basic FUNCTION
  • translation factor, stimulating the initiation of protein synthesis at the mRNA level
  • with EIF4B contribute to RNA affinity of the complex through weak interactions not detectable in structural assays (Rozovsky 2008)
  • plays a crucial role in translational control and can promote cellular transformation by preferentially regulating the translation of potent growth and survival factor mRNAs
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of eIF4A/4G/4H helicase complex (Marintchev 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EIF4A
  • EIF4B
  • EIF4H is much less efficient at stimulating EIF4A unwinding activity than EIF4B, implying that EIF4H is not able to completely substitute for EIF4B in duplex unwinding
  • RELA p65-dependent transcriptional activation of EIF4H increased the EIF4H protein content augmenting the rate of global protein synthesis
  • DROSHA can cleave the alternatively spliced exon 5 of the EIF4H gene
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WBS
    Susceptibility
    Variant & Polymorphism other base-pair inversion polymorphism predisposing to primarily WBS- causing microdeletions
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a promising new molecular target for cancer therapy
    ANIMAL & CELL MODELS