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FLASH GENE

Symbol

EIF4H

contributors: mct - updated : 04-05-2020

HGNC name	eukaryotic translation initiation factor 4H
HGNC id	12741

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022170 7 - 2546 NP_071496 27.4 248 . overexpressed in primary human colorectal cancer 2011 20473909 ectopic expression of EIF4H isoform 1 greatly increased the cyclin D1 level EIF4H isoform 1 plays an important role in carcinogenesis through the activation of oncogenic signaling and could be a promising molecular target for cancer therapy NM_031992 6 - 2486 NP_114381 - 228 - 2011 20473909 lack an exon

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Nervous nerve       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two RNA recognition motifs
	a C terminal transmembrane region

HOMOLOGY

interspecies

homolog to murine Wbscr1

intraspecies

homolog to RNA-binding proteins

Homologene

FAMILY

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
	intracellular,nuclear envelope

basic FUNCTION	translation factor, stimulating the initiation of protein synthesis at the mRNA level
	with EIF4B contribute to RNA affinity of the complex through weak interactions not detectable in structural assays (Rozovsky 2008)
	plays a crucial role in translational control and can promote cellular transformation by preferentially regulating the translation of potent growth and survival factor mRNAs

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of eIF4A/4G/4H helicase complex (Marintchev 2008)

INTERACTION

DNA

RNA

small molecule

protein	EIF4A
	EIF4B
	EIF4H is much less efficient at stimulating EIF4A unwinding activity than EIF4B, implying that EIF4H is not able to completely substitute for EIF4B in duplex unwinding
	RELA p65-dependent transcriptional activation of EIF4H increased the EIF4H protein content augmenting the rate of global protein synthesis
	DROSHA can cleave the alternatively spliced exon 5 of the EIF4H gene

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

WBS

Susceptibility

Variant & Polymorphism other	base-pair inversion polymorphism predisposing to primarily WBS- causing microdeletions

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   is a promising new molecular target for cancer therapy

ANIMAL & CELL MODELS