| Symbol
| NRCAM
| contributors: mct - updated : 23-03-2022
|
| HGNC name
| neuronal cell adhesion molecule
|
| HGNC id
| 7994
|
| corresponding disease(s)
|
DDHNS
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
overexpressed in papillary thyroid carcinomas at the mRNA and protein levels, whatever the tumour stage  | | tumoral
|
|
| --over
|
| |
in papillary thyroid cancer (PTCs) | |
| Susceptibility
|
to autism (AUTS1) |
| Variant & Polymorphism
SNP
| seven SNPs in the NRCAM gene were significantly associated with autism, among which rs2300045 is the most prominent |
| 
|
| Candidate gene
| for AUTS9 |
| Marker
| may represent a potential diagnostic marker for thyroid cancer |
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | endocrine | thyroid | |
| may represent a potential therapeutic target for thyroid cancer |
| |
|
| concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis | |
peripheral nerves of Nrcam-deficient mice exhibit delayed or abnormal node formation |