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FLASH GENE
Symbol NRCAM contributors: mct - updated : 23-03-2022
HGNC name neuronal cell adhesion molecule
HGNC id 7994
ASSOCIATED DISORDERS
corresponding disease(s) DDHNS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
overexpressed in papillary thyroid carcinomas at the mRNA and protein levels, whatever the tumour stage
tumoral     --over  
in papillary thyroid cancer (PTCs)
Susceptibility to autism (AUTS1)
Variant & Polymorphism SNP
  • seven SNPs in the NRCAM gene were significantly associated with autism, among which rs2300045 is the most prominent
  • Candidate gene for AUTS9
    Marker
  • may represent a potential diagnostic marker for thyroid cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinethyroid
    may represent a potential therapeutic target for thyroid cancer
    ANIMAL & CELL MODELS
  • concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis
  • peripheral nerves of Nrcam-deficient mice exhibit delayed or abnormal node formation