immunoglobulin superfamily L1/NgCAM and neurofascin related
L1 family of cell adhesion molecules
CATEGORY
adhesion
SUBCELLULAR LOCALIZATION
extracellular
plasma membrane
basic FUNCTION
involved in axon growth
playing a possible role in the maturation or stabilization of the synaptic contacts, in particular between climbing fibers and Purkinje cells
CNTN1, CNTN2 and L1-like proteins (NRCAM) play a significant role in modulating SHH-induced neuronal precursor proliferation
required for normal maturation of cortical visual acuity
functions in cell adhesion and modulates signaling pathways in neural development through multiple molecular interactions with guidance and other factors
is a regulator of axon growth and repellent guidance, and has been implicated in autism spectrum disorders
neuronal cell adhesion molecule involved in neuron-neuron and neuron-glial adhesion as well as directional signaling during axonal cone growth
has been shown to be involved in several cellular processes in the central and peripheral nervous systems, including neurite outgrowth, axonal pathfinding and myelination, fasciculation of nerve fibers, and cell migration
role for NRCAM in the pathfinding of spiral ganglion dendrites toward their hair cell targets in the sensory epithelium
NRCAM-dependent function for ADAM10 in neurite outgrowth
neuronal cell adhesion molecule involved in neural development
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
interacting with CNTN2 (role in the development of the cerebellar system)
initial clustering of Na(+) channels at heminodes requires glial NRCAM and GLDN, as well as their axonal receptor neurofascin 186 (NFASC186)
interaction with neuropilin-2 is critical for semaphorin 3F (SEMA3F)-induced guidance of thalamocortical axon subpopulations at the ventral telencephalon, an intermediate target for thalamic axon sorting
in the peripheral nervous system (PNS), the axoglial contact mediated by the binding of glial GLDN and NRCAM to axonal NFASC186 is crucial for the initial clustering of voltage-gated Na+ channels at the nodes of Ranvier
contributes to mediolateral retinocollicular axon targeting by regulating retinal ganglion cells (RGCs) branch orientation through a likely mechanism in which ephrinB/EphB phosphorylates NRCAM to modulate linkage to the actin cytoskeleton
is a novel postnatal regulator of dendritic spine density in cortical pyramidal neurons, and an integral component of the SEMA3F receptor complex
mediate spine pruning as a subunit of the receptor complex for the repellent ligand SEMA3F
NRCAM stabilizes binding between NRP2 and PLXNA3 necessary for SEMA3F-induced spine pruning
