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FLASH GENE
Symbol TUSC3 contributors: mct - updated : 16-01-2019
HGNC name tumor suppressor candidate 3
HGNC id 30242
ASSOCIATED DISORDERS
corresponding disease(s) MRAR5
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in prostate cancer
tumoral     --over  
in papillary thyroid carcinoma
tumoral     --low  
in grade 3 tumors compared with tumors of lower grade
tumoral     --low  
in several ovarian cancer cell lines
constitutional       loss of function
inactivation through methylation of TUSC3 and ESR1 associated with ulcerative colitis, but not with colrectal carcinoma
tumoral     --low  
in hepatocellular carcinoma
tumoral     --low  
in esophageal squamous carcinoma
Susceptibility prostate cancer
Variant & Polymorphism SNP
Candidate gene
Marker
  • has potential to be used as prognostic markers in Colorectal Cancer
  • could be used as an independent predictor of prognosis in hepatocellular carcinoma patients
  • decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients and decreased TUSC3 promotes pancreatic cancer cell proliferation, invasion and metastasis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    has potential to be used as therapeutic targets in CRC
    ANIMAL & CELL MODELS