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FLASH GENE

Symbol

TUSC3

contributors: mct - updated : 16-01-2019

HGNC name	tumor suppressor candidate 3
HGNC id	30242

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006765 11 splicing 3888 NP_006756 39 348 - 2000 10673282 NM_178234 10 splicing 3823 NP_839952 - 347 - 2000 10673282 NM_001356429 11 - 4092 NP_001343358 - 348 - 2000 10673282

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       liver       highly Endocrine pancreas       highly Hearing/Equilibrium ear inner cochlea   highly Nervous brain         Reproductive male system prostate     highly Respiratory lung       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a membrane-anchored N-terminal thioredoxin domain located in the ER lumen that may form transient mixed disulfide complexes with DDOST substrates
	four transmembrane domains (4TM)

HOMOLOGY

interspecies

homolog to rattus Lag2

Homologene

FAMILY

OST3 family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	localizes to the endoplasmic reticulum

basic FUNCTION	putative prostate cancer tumor supressor
	catalyzes the transfer of an oligosaccharide chain on nascent proteins, the key step of N-glycosylation
	STK11, TP53, TUSC3 might play a role in the development of metastasis in larynx and pharynx squamous cell carcinomas (
	MAGT1 and TUSC3 are indispensable members of the vertebrate plasma membrane Mg(2+) transport system
	required for cellular Mg2+ uptake )
	play a central role in vertebrate embryonic development that cannot be compensated by other putative Mg2+ transporters
	role for N-glycosylating events in ovarian cancer pathogenesis and TUSC3 is a tumor suppressor gene in ovarian cancer in particular
	functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response
	possible role of TUSC3 beyond endoplasmic reticulum
	may act as an oncogene in the progression of colorectal cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TUSC3 induces autophagy in non-small cell lung cancer cells through activation of the Wnt/CTNNB1 signaling pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRAR5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in prostate cancer tumoral     --over   in papillary thyroid carcinoma tumoral     --low   in grade 3 tumors compared with tumors of lower grade tumoral     --low   in several ovarian cancer cell lines constitutional       loss of function inactivation through methylation of TUSC3 and ESR1 associated with ulcerative colitis, but not with colrectal carcinoma tumoral     --low   in hepatocellular carcinoma tumoral     --low   in esophageal squamous carcinoma

Susceptibility

prostate cancer

Variant & Polymorphism SNP

Candidate gene
Marker	has potential to be used as prognostic markers in Colorectal Cancer
	could be used as an independent predictor of prognosis in hepatocellular carcinoma patients
	decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients and decreased TUSC3 promotes pancreatic cancer cell proliferation, invasion and metastasis
Therapy target
	System Type Disorder Pubmed cancer digestive colon has potential to be used as therapeutic targets in CRC

ANIMAL & CELL MODELS