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FLASH GENE
Symbol TUSC3 contributors: mct - updated : 16-01-2019
HGNC name tumor suppressor candidate 3
HGNC id 30242
Corresponding disease
MRAR5 mental retardation, non-syndromic 5
Location 8p22      Physical location : 15.397.729 - 15.621.993
Genatlas name see TSG8A
Synonym name
  • putative prostate cancer tumor suppressor
  • oligosaccharyltransferase 3A, OTase 3A
  • magnesium uptake/transporter TUSC3
    • Synonym symbol(s) D851992, N33, MGC13453, OST3A, MAGT2
    DNA
    TYPE functioning gene
    STRUCTURE 226.56 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D8S511 - (D8S1731 - [TUSC3 , D8S1992 - D8S549 - D8S602 ) - MSR1 - D8S2066 ] - D8S1715 -cen
    Authors Arbieva (00)
    Text [prostate cancer deletion],(pancreas cancer deletion)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 3888 39 348 - 2000 10673282
    10 splicing 3823 - 347 - 2000 10673282
    11 - 4092 - 348 - 2000 10673282
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver   highly
    Endocrinepancreas   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a membrane-anchored N-terminal thioredoxin domain located in the ER lumen that may form transient mixed disulfide complexes with DDOST substrates
  • four transmembrane domains (4TM)
    • HOMOLOGY
    interspecies homolog to rattus Lag2
    Homologene
    FAMILY OST3 family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localizes to the endoplasmic reticulum
    basic FUNCTION
  • putative prostate cancer tumor supressor
  • catalyzes the transfer of an oligosaccharide chain on nascent proteins, the key step of N-glycosylation
  • STK11, TP53, TUSC3 might play a role in the development of metastasis in larynx and pharynx squamous cell carcinomas (
  • MAGT1 and TUSC3 are indispensable members of the vertebrate plasma membrane Mg(2+) transport system
  • required for cellular Mg2+ uptake )
  • play a central role in vertebrate embryonic development that cannot be compensated by other putative Mg2+ transporters
  • role for N-glycosylating events in ovarian cancer pathogenesis and TUSC3 is a tumor suppressor gene in ovarian cancer in particular
  • functions in final steps of N-glycosylation of proteins, while its loss evokes the unfolded protein response
  • possible role of TUSC3 beyond endoplasmic reticulum
  • may act as an oncogene in the progression of colorectal cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TUSC3 induces autophagy in non-small cell lung cancer cells through activation of the Wnt/CTNNB1 signaling pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRAR5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in prostate cancer
    tumoral     --over  
    in papillary thyroid carcinoma
    tumoral     --low  
    in grade 3 tumors compared with tumors of lower grade
    tumoral     --low  
    in several ovarian cancer cell lines
    constitutional       loss of function
    inactivation through methylation of TUSC3 and ESR1 associated with ulcerative colitis, but not with colrectal carcinoma
    tumoral     --low  
    in hepatocellular carcinoma
    tumoral     --low  
    in esophageal squamous carcinoma
    Susceptibility prostate cancer
    Variant & Polymorphism SNP
    Candidate gene
    Marker
  • has potential to be used as prognostic markers in Colorectal Cancer
  • could be used as an independent predictor of prognosis in hepatocellular carcinoma patients
  • decreased immunological TUSC3 staining is a factor prognostic of poor survival in pancreatic cancer patients and decreased TUSC3 promotes pancreatic cancer cell proliferation, invasion and metastasis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    has potential to be used as therapeutic targets in CRC
    ANIMAL & CELL MODELS