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FLASH GENE

Symbol

PTK2B

contributors: mct - updated : 26-06-2017

HGNC name	PTK2B protein tyrosine kinase 2 beta
HGNC id	9612

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in the human heart during heart failure may contribute to protection against arrhythmia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed osteoarticular     may be important for therapeutic interventions aimed at increasing bone formation in metabolic diseases of the skeleton miscelleaneous urinary   new therapeutic target for ameliorating renal fibrosis

ANIMAL & CELL MODELS

mice lacking Pyk2 exhibit an increase in bone mass, in part due to impairment of osteoclast function