| 1 | CD9, IZUMO1R, PTK2B
|
| Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site†
|
| Wang H, Hong X, Kinsey WH.
|
| Biol Reprod. Jun 4;104(6):1292-1301. doi: 10.1093/biolre/ioab048. 2021
|
| 2 | CXCL12, PTK2B, STAP2
|
| STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells.
|
| Saitoh K, Tsuchiya T, Kashiwakura JI, Muromoto R, Kitai Y, Sekine Y, Oritani K, Matsuda T.
|
| Biochem Biophys Res Commun 488(1):81-87. doi: 10.1016/j.bbrc.2017.05.010. Epub 2017 May 3.
2017
|
| 3 | PTK2, PTK2B, PYCARD
|
| Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
|
| Chung IC, OuYang CN, Yuan SN, Li HP, Chen JT, Shieh HR, Chen YJ, Ojcius DM, Chu CL, Yu JS, Chang YS, Chen LC.
|
| Sci Rep 6:36214. doi: 10.1038/srep36214.
2016
|
| 4 | CBLB, PTK2B
|
| Cbl-b accelerates trypsin-induced cell detachment through ubiquitination and degradation of proline-rich tyrosine kinase 2.
|
| Fan Y, Qu X, Ma Y, Qu J, Liu Y, Hu X.
|
| Tumour Biol 35(11):11129-35. doi: 10.1007/s13277-014-2296-z. Epub 2014 Aug 7.
2014
|
| 5 | CCL18, PITPNM3, PTK2B
|
| Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis.
|
| Li HY, Cui XY, Wu W, Yu FY, Yao HR, Liu Q, Song EW, Chen JQ.
|
| J Cell Biochem 115(3):596-603. doi: 10.1002/jcb.24697.
2014
|
| 6 | PTK2B, PTPN12, PXN
|
| Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12.
|
| Rhee I, Davidson D, Souza CM, Vacher J, Veillette A.
|
| Mol Cell Biol 33(12):2458-69. doi: 10.1128/MCB.00197-13. Epub 2013 Apr 15.
2013
|
| 7 | ITGA2B, ITGB3, PTK2B
|
| The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.
|
| Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M.
|
| J Thromb Haemost 11(2):345-56. doi: 10.1111/jth.12099.
2013
|
| 8 | PTK2, PTK2B
|
| Regulation of osteoclast structure and function by FAK family kinases.
|
| Ray BJ, Thomas K, Huang CS, Gutknecht MF, Botchwey EA, Bouton AH.
|
| J Leukoc Biol 92(5):1021-8. doi: 10.1189/jlb.0512259. Epub 2012 Aug 31.
2012
|
| 9 | PTK2B, PTPN5
|
| Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity.
|
| Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ.
|
| J Biol Chem 287(25):20942-56. doi: 10.1074/jbc.M112.368654. Epub 2012 Apr 27.
2012
|
| 10 | PTK2B
|
| Megakaryocytes regulate expression of Pyk2 isoforms and caspase-mediated cleavage of actin in osteoblasts.
|
| Kacena MA, Eleniste PP, Cheng YH, Huang S, Shivanna M, Meijome TE, Mayo LD, Bruzzaniti A.
|
| J Biol Chem 287(21):17257-68. doi: 10.1074/jbc.M111.309880. Epub 2012 Mar 23.
2012
|
| 11 | PTK2B, PTPN12
|
| Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.
|
| Eleniste PP, Du L, Shivanna M, Bruzzaniti A.
|
| Int J Biochem Cell Biol 44(5):790-800. doi: 10.1016/j.biocel.2012.01.022. Epub 2012 Feb 8.
2012
|
| 12 | PTK2B
|
| The kinase Pyk2 is involved in renal fibrosis by means of mechanical stretch-induced growth factor expression in renal tubules.
|
| Sonomura K, Okigaki M, Kimura T, Matsuoka E, Shiotsu Y, Adachi T, Kado H, Ishida R, Kusaba T, Matsubara H, Mori Y.
|
| Kidney Int 81(5):449-57. doi: 10.1038/ki.2011.403. Epub 2011 Dec 7. Erratum in: Kidney Int. 2012 Jun;81(12):1280.
2012
|
| 13 | PTK2, PTK2B, XIAP
|
| XIAP reverses various functional activities of FRNK in endothelial cells.
|
| Ahn S, Kim HJ, Chi SG, Park H.
|
| Biochem Biophys Res Commun 419(2):419-24. doi: 10.1016/j.bbrc.2012.02.037. Epub 2012 Feb 14.
2012
|
| 14 | PTK2B, RELA
|
| Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2.
|
| Bijli KM, Fazal F, Rahman A.
|
| Am J Respir Cell Mol Biol 47(5):660-8. doi: 10.1165/rcmb.2012-0047OC. Epub 2012 Jul 27.
2012
|
| 15 | NPHP1, NPHP4, PACS1, PTK2B
|
| Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia.
|
| Liebau MC, Höpker K, Müller RU, Schmedding I, Zank S, Schairer B, Fabretti F, Höhne M, Bartram MP, Dafinger C, Hackl M, Burst V, Habbig S, Zentgraf H, Blaukat A, Walz G, Benzing T, Schermer B.
|
| J Biol Chem 286(16):14237-45. Epub 2011 Feb 28.
2011
|
| 16 | PTK2B
|
| A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells.
|
| Liang L, Woodward OM, Chen Z, Cotter R, Guggino WB.
|
| PLoS One 6(7):e21991. doi: 10.1371/journal.pone.0021991. Epub 2011 Jul 13.
2011
|
| 17 | PTK2B
|
| Role of Pyk2 in cardiac arrhythmogenesis.
|
| Lang D, Glukhov AV, Efimova T, Efimov IR.
|
| Am J Physiol Heart Circ Physiol 301(3):H975-83. doi: 10.1152/ajpheart.00241.2011. Epub 2011 Jun 10.
2011
|
| 18 | PTK2B
|
| Hypophosphorylated and inactive Pyk2 associates with paxillin at the microtubule organizing center in hematopoietic cells.
|
| St-Pierre J, Lysechko TL, Ostergaard HL.
|
| Cell Signal 23(4):718-30. doi: 10.1016/j.cellsig.2010.12.006. Epub 2010 Dec 31.
2011
|
| 19 | MYD88, PTK2B
|
| PYK2 interacts with MyD88 and regulates MyD88-mediated NF-kappaB activation in macrophages.
|
| Xi CX, Xiong F, Zhou Z, Mei L, Xiong WC.
|
| J Leukoc Biol 87(3):415-23. Epub 2009 Dec 2.PMID: 19955209 2010
|
| 20 | PTK2, PTK2B
|
| The influence of Pyk2 on the mechanical properties in fibroblasts.
|
| Klemm AH, Kienle S, Rheinlaender J, Schäffer TE, Goldmann WH.
|
| Biochem Biophys Res Commun 393(4):694-7. Epub 2010 Feb 17.
2010
|
| 21 | PTK2B
|
| Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads.
|
| Beverdam A, Svingen T, Bagheri-Fam S, McClive P, Sinclair AH, Harley VR, Koopman P.
|
| Dev Dyn 239(10):2735-41. doi: 10.1002/dvdy.22396.
2010
|
| 22 | PTK2B, PTPN12
|
| The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.
|
| Davidson D, Shi X, Zhong MC, Rhee I, Veillette A.
|
| Immunity 33(2):167-80. doi: 10.1016/j.immuni.2010.08.001.
2010
|
| 23 | PTK2B
|
| T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.
|
| Collins M, Bartelt RR, Houtman JC.
|
| Mol Immunol 47(9):1665-74. doi: 10.1016/j.molimm.2010.03.009. Epub 2010 Apr 9.
2010
|
| 24 | EIF4B, PTK2B
|
| AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.
|
| van Gorp AG, van der Vos KE, Brenkman AB, Bremer A, van den Broek N, Zwartkruis F, Hershey JW, Burgering BM, Calkhoven CF, Coffer PJ.
|
| Oncogene 28(1):95-106. Epub 2008 Oct 6.
2009
|
| 25 | ARHGEF11, PTK2B
|
| PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA.
|
| Ying Z, Giachini FR, Tostes RC, Webb RC.
|
| Arterioscler Thromb Vasc Biol 29(10):1657-63. doi: 10.1161/ATVBAHA.109.190892.
2009
|
| 26 | PTK2, PTK2B
|
| B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.
|
| Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.
|
| J Biol Chem 284(34):22865-77. doi: 10.1074/jbc.M109.013169. Epub 2009 Jun 26.
2009
|
| 27 | PTK2B
|
| Identification of a functional protein kinase Cbeta promoter polymorphism in humans related to insulin resistance.
|
| Osterhoff MA, Heuer S, Pfeiffer M, Tasic J, Kaiser S, Isken F, Spranger J, Weickert MO, Möhlig M, Pfeiffer AF.
|
| Mol Genet Metab 93(2):210-5. Epub 2007 Oct 22.
2008
|
| 28 | PTK2B
|
| CRNK gene transfer improves function and reverses the myosin heavy chain isoenzyme switch during post-myocardial infarction left ventricular remodeling.
|
| Hart DL, Heidkamp MC, Iyengar R, Vijayan K, Szotek EL, Barakat JA, Leya M, Henze M, Scrogin K, Henderson KK, Samarel AM.
|
| J Mol Cell Cardiol 45(1):93-105. Epub 2008 Apr 16.
2008
|
| 29 | PTK2B
|
| The role of proline-rich protein tyrosine kinase 2 in differentiation-dependent signaling in human epidermal keratinocytes.
|
| Schindler EM, Baumgartner M, Gribben EM, Li L, Efimova T.
|
| J Invest Dermatol 127(5):1094-106. Epub 2007 Jan 4.
2007
|
| 30 | NPHP1, NPHP4, TTC8, BCAR1, PTK2B
|
| Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.
|
| Mollet G, Silbermann F, Delous M, Salomon R, Antignac C, Saunier S.
|
| Hum Mol Genet 14(5):645-56. Epub 2005 Jan 20. 2005
|
| 31 | BCAR1, NPHP4, PTK2B
|
| A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution.
|
| Otto E, Hoefele J, Ruf R, Mueller AM, Hiller KS, Wolf MT, Schuermann MJ, Becker A, Birkenhager R, Sudbrak R, Hennies HC, Nurnberg P, Hildebrandt F.
|
| Am J Hum Genet 71(5):1161-7. 2002
|
| 32 | PTK2B
|
| Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts.
|
| Zhang Z, Neff L, Bothwell AL, Baron R, Horne WC.
|
| Bone 31(3):359-65.
2002
|
| 33 | GSK3B, PTK2B
|
| Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2.
|
| Hartigan JA, Xiong WC, Johnson GV.
|
| Biochem Biophys Res Commun 284(2):485-9. 2001
|
| 34 | PTK2B
|
| RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes.
|
| Ganju RK, et al.
|
| J Exp Med 185 : 1055-1063. 1997
|
| 35 | PTK2B
|
| Precise localization of the human gene encoding cell adhesion kinase beta (CAKbeta/PYK2) to chromosome 8 at p21.1 by fluorescence in situ hybridization.
|
| Inazawa J, et al.
|
| Hum Genet 98 : 508-510. 1996
|
| 36 | PTK2B
|
| Molecular cloning and assignment of FAK2, a novel human focal adhesion kinase, to 8p11.2-p22 by nonisotopic in situ hybridization.
|
| Herzog H, et al.
|
| Genomics 32 : 484-486. 1996
|
| 37 | PTK2B
|
| Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain.
|
| Avraham S, et al.
|
| J Biol Chem 270 : 27742-27751. 1995
|
| 38 | PTK2B
|
| Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily.
|
| Sasaki H, et al.
|
| J Biol Chem 270 : 21206-21219. 1995
|
| 39 | PTK2B
|
| Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
|
| Lev S, et al.
|
| Nature 376 : 737-745. 1995
|
| 40 | PTK2B, TNK2
|
| A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.
|
| Manser E, Leung T, Salihuddin H, Tan L, Lim L.
|
| Nature 363(6427):364-7. 1993
|