basic FUNCTION
| involved in the transport of hydrophobic ligands (retinol transport)and of small lipophilic substances |
|
modulator of inflammation (prostaglandin synthesis) |
|
immune system homeostasis |
|
suppressing growth induced by IL3, but not influencing CSF3-dependent cell growth |
|
iron-siderophore-binding protein, converting embryonic kidney mesenchyme to epithelia |
|
epithelial inducer in Ras malignancy and suppressor of metastasis |
|
iron transporter with functions distinct from that of transferrin and mediating a new iron-delivery pathway |
|
lineage-specific role in hematopoiesis, having important function in the regulation of hematopoiesis |
|
adipokine that potentially connects obesity and its related adipose inflammation |
|
autocrine and paracrine adipokine, acts as an antagonist to the effect of inflammatory molecules on inflammation and secretion of adipokines |
|
potential suppressor of invasion and angiogenesis in advanced pancreatic cancer |
|
important biomarker in clinical nephrology, extending to chronic kidney disease the pathophysiological role of this protein in tubular adaptations to renal damage |
|
plays a role as an iron-sequestering protein in the antibacterial innate immune response |
|
induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore |
|
may actively participate in breast cancer progression |
|
siderophore-binding antimicrobial protein, critical for control of systemic infection with Escherichia coli |
|
being a crucial component of mucosal immune defense against pulmonary infection with K. pneumoniae |
|
critical selective modulator of PPARG activation and function in lipid homeostasis and energy expenditure 8) |
|
SLC22A17, in cooperation with LCN2, is involved in the acquisition of aggressive behavior among endometrial carcinoma cells |
|
controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation |
|
promotes cell migration through up-regulation of chemokines in brain |
|
essential role for LCN2 as a protein required for the reactive astrocytosis and cell migration in the CNS |
|
LCN2 accelerated neuronal motility and process extension, suggesting multiple roles for LCN2 in the regulation of neuronal cell death, migration, and morphology |
|
LCN2-induced cardiomyocyte apoptosis is of physiological significance and occurs via a mechanism involving elevated intracellular iron levels and BAX translocation |
|
is a molecular actor in neuroinflammation in early clinical stages of Alzheimer disease |
|
novel role as an important paracrine chemoattractant and an indispensable factor for neutrophil function in inflammation |
|
promotes angiogenesis, suggesting a novel mechanism through which LCN2 may promote tumor progression |
|
STEAP4 and LCN2 mRNA and protein levels in visceral adipose tissue are related to iron status |
|
is an M1-amplifier in brain microglial cells |