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FLASH GENE

Symbol

CAPZA2

contributors: mct - updated : 15-03-2008

HGNC name	capping protein (actin filament) muscle Z-line, alpha 2
HGNC id	1490

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 10 - 2373 - 286 - Ewing (2007)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine       highly   pharynx       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Caz2

Homologene

FAMILY

F-actin capping protein alpha subunit family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION

basic FUNCTION	F-actin-capping protein that bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments,
	thereby blocking the exchange of subunits at these ends

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer of an alpha and a beta subunit

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS