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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

DAPK1

contributors: mct/pgu - updated : 15-11-2019

HGNC name	death-associated protein kinase 1
HGNC id	2674

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         by hypermethylation in head and neck carcinomas tumoral     --low   by promoter methylation in B cell chronic lymphocytic leukemia and chronic myeloid leukemia (promoter methylation might play a significant role in the progression of CML)

Susceptibility

to late-onset Alzheimer's disease to chronic lymphocytic leukemia

Variant & Polymorphism SNP	significantly associated with late-onset Alzheimer's disease
	downregulation in familial chronic lymphocytic leukemia

Candidate gene	for sensitive detection in plasma or serum of cancer gastric, lung cancer, head and neck cancer, by DNA methylation markers
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   for the development of novel treatment regimens in chronic lymphocytic leukemia involving epigenetic therapies for gene reactivation cancer digestive liver potential therapeutic targets for HCC

ANIMAL & CELL MODELS