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FLASH GENE
Symbol DAPK1 contributors: mct/pgu - updated : 31-08-2009
HGNC name death-associated protein kinase 1
HGNC id 2674
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral        
by hypermethylation in head and neck carcinomas
tumoral     --low  
by promoter methylation in B cell chronic lymphocytic leukemia and chronic myeloid leukemia (promoter methylation might play a significant role in the progression of CML)
Susceptibility
  • to late-onset Alzheimer's disease
  • to chronic lymphocytic leukemia
  • Variant & Polymorphism SNP
  • significantly associated with late-onset Alzheimer's disease
  • downregulation in familial chronic lymphocytic leukemia
  • Candidate gene for sensitive detection in plasma or serum of cancer gastric, lung cancer, head and neck cancer, by DNA methylation markers
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    for the development of novel treatment regimens in chronic lymphocytic leukemia involving epigenetic therapies for gene reactivation
    ANIMAL & CELL MODELS