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FLASH GENE
Symbol FSCN1 contributors: mct - updated : 06-05-2020
HGNC name fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
HGNC id 11148
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
upregulated in several epithelial neoplasms and contributing to an invasive phenotype
tumoral     --over  
in non-small cell lung cancer
tumoral     --over  
leads to increases in cell migration and invasion in breastr cancer
tumoral     --over  
in breast tumor has been associated with lung metastasis, and fascin is one of the top performing lung metastasis signature genes
tumoral     --over  
expressed higher in tongue squamous cell carcinoma (TSCC) cells than in normal cells
tumoral     --over  
in the invasive group of Pituitary Adenomas
tumoral       gain of function
in colorectal cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • over-expression of FSCN1 indicates worse prognosis for patients with tongue squamous cell carcinoma (TSCC) and FSCN1 may be a potential prognostic biomarker
  • FSCN1 is an oncogene and a potential novel prognostic biomarker for renal cell carcinoma (RCC) patients after nephrectomy, and can promote RCC metastasis
  • FSCN1 expression can be used as a predictor for transformation and progression of urothelial carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    FSCN1 is an attractive novel target for inhibiting invasion and metastasis of EOC cells
    cancerlung 
    may be a target of intervening to prevent the metastasis of non-small cell lung cancer
    cancerdigestivecolon
    targeting BMI1 and FSCN1 may provide potential therapeutic opportunity in colorectal cancer
    cancerurinary 
    reduction of fascin levels may represent a novel therapeutic strategy for urothelial carcinoma of the bladder
    ANIMAL & CELL MODELS