Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FSCN1 contributors: mct - updated : 06-05-2020
HGNC name fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
HGNC id 11148
Location 7p22.1      Physical location : 5.632.453 - 5.646.285
Synonym name
  • fascin 1
  • singed (Drosophila)-like (sea urchin fascin homolog like)
  • actin bundling protein
  • 55 kDa actin-bundling protein
  • epididymis secretory sperm binding protein
    • Synonym symbol(s) SNL, EVI74, SNL, p55, fascin, FLJ38511, FAN1, HSN, FLJ43305
    DNA
    TYPE functioning gene
    STRUCTURE 13.86 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    cytosine-phosphate-guanine/HTF
    text structure a core promoter region, with a putative GC box, a composite cAMP responsive element/AP-1 binding site and a TATA box
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2819 - 493 - 2010 20434460
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Rattus norvegicus
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Reproductivegerm cell Rattus norvegicus
    ReproductiveSertoli cell Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • protein kinase C phosphorylation site
  • four fascin domains
  • four tandem beta-trefoil domains that form a bi-lobed structure with approximate pseudo 2-fold symmetry
  • a C terminal half actin-binding domain
    • HOMOLOGY
    interspecies homolog to sea urchin fascin
    homolog to Drosophila singed
    Homologene
    FAMILY
  • fascin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • cortical cell protrusions and cytoplasmic microfilament bundles
  • present predominantly in filopodia, which are believed to play a central role in normal and aberrant cell migration
    • basic FUNCTION
  • actin-bundling protein have involvd in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture
  • involved in the organization of the actin cytoskeleton in cytoplasmatic extensions of nerve growth cones
  • necessary for the formation of the dendritic processes of maturing Langerhans cells and may thus influence T cell-Epidermal Langerhans cells interaction
  • required for TGFB1-induced filopodia formation, cell migration, and invasion
  • played potentially a central role in the invasive machinery mobilized by TGFB1 in spindle tumor cells and by stabilizing actin cytoskeleton within invadopodia and filopodia, fascin coordinates the invasion and metastasis promoted by TGFB1
  • FSCN1 and CFL1 act synergistically in filament severing
  • CFL1 cooperates with FSCN1 to disassemble filopodial actin filaments
  • promotes filopodia formation, migration and invasion in carcinoma cells
  • FSCN1 is associated consistently with increased risk of mortality in breast, colorectal and esophageal carcinomas and with metastasis in colorectal and gastric carcinomas
  • actin-bundling protein, associated with increased risk of mortality and metastasis in various cancer types
  • is an F-actin-bundling protein shown to stabilize filopodia and regulate adhesion dynamics in migrating cells, and its expression is correlated with poor prognosis and increased metastatic potential in a number of cancers
  • role for fascin that operates independently of filopodia assembly to promote efficient cell migration and invasion
  • is a cytoskeleton-associated protein recognized to function primarily in the regulation of cytoskeleton structure and formation of plasma membrane protrusions
  • having nuclear function as an epigenetic modulator of genes essential for amino acid metabolism
  • both CTTN and FSCN1 play key roles in extracellular vesicles (EVs) release by regulating endosomal trafficking or invadopodia formation and function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta-catenin
  • immediate TGFbeta target gene essential for its pro-invasion activity, and TGFB might be responsible for the fascin overexpression in some metastatic tumors
  • TGFB1 target gene regulated by SMAD3 and SMAD4
  • SYNE2 interacts with FSCN1 through a direct, F-actin-independent interaction, and this binding is distinct and separable from a role for fascin within filopodia at the cell periphery
  • functional linkage between NSMCE3, VIM and FSCN1
  • FSCN1 promote Epithelial-mesenchymal transition (EMT) through SNAI1 in ovarian cancer cells
  • SOX2 mediates the expression of HBEGF and FSCN1 by activating AKT1 and CTNNB1 signaling pathways
    • cell & other
    REGULATION
    activated by TGFBeta, that elevates fascin protein expression and promotes invasion and filopodia formation in tumor cells with spindle morphology, but not in tumor cells with epithelial-like, polygonal morphology
    inhibited by migrastatin
    Other regulated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    upregulated in several epithelial neoplasms and contributing to an invasive phenotype
    tumoral     --over  
    in non-small cell lung cancer
    tumoral     --over  
    leads to increases in cell migration and invasion in breastr cancer
    tumoral     --over  
    in breast tumor has been associated with lung metastasis, and fascin is one of the top performing lung metastasis signature genes
    tumoral     --over  
    expressed higher in tongue squamous cell carcinoma (TSCC) cells than in normal cells
    tumoral     --over  
    in the invasive group of Pituitary Adenomas
    tumoral       gain of function
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • over-expression of FSCN1 indicates worse prognosis for patients with tongue squamous cell carcinoma (TSCC) and FSCN1 may be a potential prognostic biomarker
  • FSCN1 is an oncogene and a potential novel prognostic biomarker for renal cell carcinoma (RCC) patients after nephrectomy, and can promote RCC metastasis
  • FSCN1 expression can be used as a predictor for transformation and progression of urothelial carcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    FSCN1 is an attractive novel target for inhibiting invasion and metastasis of EOC cells
    cancerlung 
    may be a target of intervening to prevent the metastasis of non-small cell lung cancer
    cancerdigestivecolon
    targeting BMI1 and FSCN1 may provide potential therapeutic opportunity in colorectal cancer
    cancerurinary 
    reduction of fascin levels may represent a novel therapeutic strategy for urothelial carcinoma of the bladder
    ANIMAL & CELL MODELS