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FLASH GENE

Symbol

TPM2

contributors: mct/npt - updated : 09-05-2018

HGNC name	tropomyosin 2 (beta)
HGNC id	12011

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Reproductive female system uterus     highly Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

dimer

HOMOLOGY

interspecies

homolog to murine Tpm2

Homologene

FAMILY

tropomyosin family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	actin-binding protein, which is localized head to tail along the length of the actin filament (Nilsson 2008)
	playing a central role in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction
	is a potential novel tumour suppressor gene in breast cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

AMCD1 , NEM4 , SHHS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function impaired the differentiation of MSCs by significant reduction of adipogenesis and osteogenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neuromuscular myopathy congenital administration of troponin activators may constitute a promising therapeutic approach to minimize generalized skeletal muscle weakness in Nemaline myopathy cancer reproductive breast may represent a promising therapeutic gene target for breast cancer patients with chemoresistance

ANIMAL & CELL MODELS

among the Tpm2 mutations associated with skeletal myopathies, the Tpm2E122K mutation was found to reduce Tpm2 expression and impair spatial learning and memory in rats