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FLASH GENE
Symbol TPM2 contributors: mct/npt - updated : 09-05-2018
HGNC name tropomyosin 2 (beta)
HGNC id 12011
Corresponding disease
AMCD1 arthrogryposis multiplex congenita, distal, type IA
NEM4 nemaline myopathy 4
SHHS2 Sheldon-Hall syndrome 2
Location 9p13.3      Physical location : 35.681.989 - 35.690.053
Synonym name beta-tropomyosin
Synonym symbol(s) DA1, TMSB, DA2B, AMCD1, HEL-S-273, NEM4, TROP2
DNA
TYPE functioning gene
STRUCTURE 8.07 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif
MAPPING cloned Y linked N status confirmed
Map pter - D9S165 - TPM2 - D9S1705 - D9S166 - cen
Authors Tiso (97)
Physical map
DNAJB5 9p11.2 DnaJ (Hsp40) homolog, subfamily B, member 5 LOC392306 9 similar to GCIP-interacting protein p29 LOC138724 VCP 9p13-p12 valosin-containing protein FANCG 9p13 Fanconi anemia, complementation group G PIGO 9p13.2 phosphatidylinositol glycan, class O STOML2 9p13 stomatin (EPB72)-like 2 FLJ11560 9p13.2 hypothetical protein FLJ11560 LOC347241 9p13.2 similar to Zinc finger protein 492 UNC13B 9p12-p11 unc-13 homolog B (C. elegans) PRO0038 9p13.2 PRO0038 protein LOC389717 9 hypothetical gene supported by BC035229; BC047452 RUSC2 9p13.2 RUN and SH3 domain containing 2 LOC138729 9p13.2 hypothetical gene LOC138729 TESK1 9p13 testis-specific kinase 1 CD72 9p13.1 CD72 antigen SIT 9p13-p12 CD72 antigen MGC31967 9p13.2 hypothetical protein MGC31967 FLJ14642 9p13.2 hypothetical protein FLJ14642 CA9 9p13-p12 carbonic anhydrase IX TPM2 9p13.2-p13.1 tropomyosin 2 (beta) TLN1 9p13 talin 1 CREB3 9p13.2 cAMP responsive element binding protein 3 (luman) GBA2 9p13.3-p11.2 glucosidase, beta (bile acid) 2 KIAA0258 9pter-p22.1 KIAA0258 protein NPR2 9p21-p12 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) SPAG8 9p13-p12 sperm associated antigen 8 HINT2 9p11.2 histidine triad nucleotide binding protein 2 LOC392307 9 similar to RIKEN cDNA 4930412F15 gene NGX6 9p13.1 nasopharyngeal carcinoma related protein LOC389718 9 LOC389718 LOC392308 9 similar to Olfactory receptor 70 LOC392309 9 similar to Olfactory receptor 13J1 LOC392310 9 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) OR2S2 9p13.3-p13.1 olfactory receptor, family 2, subfamily S, member 2 LOC389719 9 hypothetical gene supported by M24070; NM_004559 LOC392311 9 similar to seven transmembrane helix receptor OR13C7P 9 olfactory receptor, family 13, subfamily C, member 7 pseudogene LOC392313 9 similar to olfactory receptor RECK 9p13-p12 reversion-inducing-cysteine-rich protein with kazal motifs C9orf19 9p12-p13 chromosome 9 open reading frame 19 CCIN 9p13-p12 calicin CLTA 9p13-p12 clathrin, light polypeptide (Lca) GNE 9p13-p12 clathrin, light polypeptide (Lca)
RNA
TRANSCRIPTS type
text in chicken, exon 6B is excluded in mRNA from myoblasts and included in mRNA from myotubes (PMID: 20875406)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1327 32.8 284 - 2015 25369766
  • Tpm2.2
  • 9 - 1182 32.8 284 - 2015 25369766
  • Tpm2.1
  • acts as a suppressor of growth on soft matrices by supporting proper rigidity sensing (PMID: 26619148)
  • 9 - 1182 - 284 - 2015 25369766
  • Tpm2.3
  • 9 - 1327 - 284 - 2015 25369766
  • Tpm2.4
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivefemale systemuterus  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Tpm2
    Homologene
    FAMILY
  • tropomyosin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • actin-binding protein, which is localized head to tail along the length of the actin filament (Nilsson 2008)
  • playing a central role in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction
  • is a potential novel tumour suppressor gene in breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AMCD1 , NEM4 , SHHS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    impaired the differentiation of MSCs by significant reduction of adipogenesis and osteogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neuromuscularmyopathycongenital
    administration of troponin activators may constitute a promising therapeutic approach to minimize generalized skeletal muscle weakness in Nemaline myopathy
    cancerreproductivebreast
    may represent a promising therapeutic gene target for breast cancer patients with chemoresistance
    ANIMAL & CELL MODELS
  • among the Tpm2 mutations associated with skeletal myopathies, the Tpm2E122K mutation was found to reduce Tpm2 expression and impair spatial learning and memory in rats