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FLASH GENE

Symbol

CDK6

contributors: mct/npt - updated : 26-09-2019

HGNC name	cyclin-dependent kinase 6
HGNC id	1777

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MCPH12

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   may link the TP53 and RB1 tumor suppressor pathways to medulloblastoma pathomechanisms tumoral   translocation     dysregulated by translocation (2;7)(p12;q21-22 ) in spleen marginal zone lymphoma and non-Hodgkin lymphoma tumoral   translocation     in B-cell lymphoproliferative disorders ( tumoral     --over   dramatically and selectively elevated in PARK2-expressing breast cancer cells ( tumoral     --over   in lymphoid malignancies

Susceptibility

to rheumatoid arthritis

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   specific therapeutic target in human lymphoid malignancies cancer hemopathy   potential therapeutic target in human lymphoid malignancies cancer hemopathy   treatment of Burkitt lymphoma cell lines with a CDK4/6 inhibitor not only caused cell cycle arrest but, unexpectedly, induced apoptosis

ANIMAL & CELL MODELS