Citations for
1CDK4, CDK6, TFE3, TFEB
CDK4/6 regulate lysosome biogenesis through TFEB/TFE3. 2020 PMID:
Yin Q, Jian Y, Xu M, Huang X, Wang N, Liu Z, Li Q, Li J, Zhou H, Xu L, Wang Y, Yang C.
J Cell Biol. Aug 3;219(8):e201911036. doi: 10.1083/jcb.201911036. 2020
2CDK4, CDK6
CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response.
Bourdeau V, Ferbeyre G.
Autophagy utophagy. 2016 Aug 17:1-2. [Epub ahead of print] 2016
3CDK6, NANOG
Nanog interact with CDK6 to regulates astrocyte cells proliferation following spinal cord injury.
Gu J, Ni Y, Xu L, Xu H, Cai Z.
Biochem Biophys Res Commun 469(4):1097-103. doi: 10.1016/j.bbrc.2015.12.053. Epub 2015 Dec 18. 2016
4CDK6, CENPE, MCPH10, MCPH11, MCPH12, MCPH13, PHC1, ZNF335
What next-generation sequencing (NGS) technology has enabled us to learn about primary autosomal recessive microcephaly (MCPH).
Morris-Rosendahl DJ, Kaindl AM.
Mol Cell Probes 29(5):271-81. doi: 10.1016/j.mcp.2015.05.015. Epub 2015 Jun 4. Review. 2015
5CDK6
CDK6 levels regulate quiescence exit in human hematopoietic stem cells.
Laurenti E, Frelin C, Xie S, Ferrari R, Dunant CF, Zandi S, Neumann A, Plumb I, Doulatov S, Chen J, April C, Fan JB, Iscove N, Dick JE.
Cell Stem Cell 16(3):302-13. doi: 10.1016/j.stem.2015.01.017. Epub 2015 Feb 19. 2015
6CDK6
CDK6 as a key regulator of hematopoietic and leukemic stem cell activation.
Scheicher R, Hoelbl-Kovacic A, Bellutti F, Tigan AS, Prchal-Murphy M, Heller G, Schneckenleithner C, Salazar-Roa M, Zöchbauer-Müller S, Zuber J, Malumbres M, Kollmann K, Sexl V.
Blood 125(1):90-101. doi: 10.1182/blood-2014-06-584417. Epub 2014 Oct 23. 2015
7CDK6, ZFP36L1
ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6.
Chen MT, Dong L, Zhang XH, Yin XL, Ning HM, Shen C, Su R, Li F, Song L, Ma YN, Wang F, Zhao HL, Yu J, Zhang JW.
Sci Rep. Nov 6;5:16229. doi: 10.1038/srep16229 2015
8CDK6, EYA2
CDK6 binds and promotes the degradation of the EYA2 protein.
Kohrt D, Crary J, Zimmer M, Patrick AN, Ford HL, Hinds PW, Grossel MJ.
Cell Cycle 13(1):62-71. doi: 10.4161/cc.26755. Epub 2013 Oct 12. 2014
9CDK6, FBXO7, PSMF1
Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction.
Shang J, Wang G, Yang Y, Huang X, Du Z.
Acta Crystallogr D Biol Crystallogr 70(Pt 1):155-64. doi: 10.1107/S1399004713025820. Epub 2013 Dec 31. 2014
10CDK4, CDK6
Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Rodríguez-Díez E, Quereda V, Bellutti F, Prchal-Murphy M, Partida D, Eguren M, Kollmann K, Gómez de Cedrón M, Dubus P, Cañamero M, Martínez D, Sexl V, Malumbres M.
Blood 124(15):2380-90. doi: 10.1182/blood-2014-02-555292. Epub 2014 Aug 25. 2014
11CDK6
SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression.
Bellail AC, Olson JJ, Hao C.
Nat Commun 5:4234. doi: 10.1038/ncomms5234. 2014
12CDK6
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, Scholl C, Fröhling S.
Blood 124(1):13-23. doi: 10.1182/blood-2014-02-558114. Epub 2014 Apr 24. 2014
13CDK6, RELA
Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression.
Handschick K, Beuerlein K, Jurida L, Bartkuhn M, Müller H, Soelch J, Weber A, Dittrich-Breiholz O, Schneider H, Scharfe M, Jarek M, Stellzig J, Schmitz ML, Kracht M.
Mol Cell 53(2):193-208. doi: 10.1016/j.molcel.2013.12.002. Epub 2014 Jan 2. Erratum in: Mol Cell. 2014 Feb 20;53(4):682. 2014
14CDK6, MCPH12
CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.
Hussain MS, Baig SM, Neumann S, Peche VS, Szczepanski S, Nürnberg G, Tariq M, Jameel M, Khan TN, Fatima A, Malik NA, Ahmad I, Altmüller J, Frommolt P, Thiele H, Höhne W, Yigit G, Wollnik B, Neubauer BA, Nürnberg P, Noegel AA.
Hum Mol Genet 22(25):5199-214. doi: 10.1093/hmg/ddt374. Epub 2013 Aug 4. 2013
15CDK6
A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.
Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V.
Cancer Cell 24(2):167-81. doi: 10.1016/j.ccr.2013.07.012. 2013
16CCND3, CDK6, TCF3
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM.
Nature 490(7418):116-20. doi: 10.1038/nature11378. Epub 2012 Aug 12. 2012
17CDK6
Cdk6-Dependent Regulation of G(1) Length Controls Adult Neurogenesis.
Beukelaers P, Vandenbosch R, Caron N, Nguyen L, Belachew S, Moonen G, Kiyokawa H, Barbacid M, Santamaria D, Malgrange B.
Stem Cells tem Cells. 2011 Feb 11. doi: 10.1002/stem.616. [Epub ahead of print] 2011
18CDK6
CDK6 kinase activity is required for thymocyte development.
Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW.
Blood 117(23):6120-31. doi: 10.1182/blood-2010-08-300517. Epub 2011 Apr 20. 2011
19CDK6, CRISPLD1, PRKN
Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells.
Tay SP, Yeo CW, Chai C, Chua PJ, Tan HM, Ang AX, Yip DL, Sung JX, Tan PH, Bay BH, Wong SH, Tang C, Tan JM, Lim KL.
J Biol Chem 285(38):29231-8. Epub 2010 Jul 14. 2010
20CDK6
Distinct subcellular distribution of cyclin dependent kinase 6.
Kohrt DM, Crary JI, Gocheva V, Hinds PW, Grossel MJ.
Cell Cycle 8(17):2837-43. Epub 2009 Sep 14. 2009
21CDK6
A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.
Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, Hu GF, Chang R, Guo Z, Dose M, Mao C, Tsichlis PN, Gounari F, Hinds PW.
Cancer Res 69(3):810-8. Epub 2009 Jan 20. 2009
22CDK6
Clinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disorders.
Chen D, Law ME, Theis JD, Gamez JD, Caron LB, Vrana JA, Dogan A.
Am J Surg Pathol 33(5):720-9. 2009
23TARDBP, CDK6
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression.
Ayala YM, Misteli T, Baralle FE.
Proc Natl Acad Sci U S A 105(10):3785-9. Epub 2008 Feb 27. 2008
24CDK6
Genome-wide association analysis identifies 20 loci that influence adult height.
Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JR, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CN, Morris AD, Ouwehand WH; Cambridge GEM Consortium, Zhao JH, Li S, Loos RJ, Barroso I, Deloukas P, Sandhu MS, Wheeler E, Soranzo N, Inouye M, Wareham NJ, Caulfield M, Munroe PB, Hattersley AT, McCarthy MI, Frayling TM.
Nat Genet 40(5):575-83. Epub 2008 Apr 6. 2008
25CD40, CDK6, MMEL1, PRKCQ
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.
Nat Genet 40(10):1216-23. Epub 2008 Sep 14. 2008
26CDK4, CDK6
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
Ruas M, Gregory F, Jones R, Poolman R, Starborg M, Rowe J, Brookes S, Peters G.
Mol Cell Biol 27(12):4273-82. Epub 2007 Apr 9. 2007
27CDK6
Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.
Mendrzyk F, Radlwimmer B, Joos S, Kokocinski F, Benner A, Stange DE, Neben K, Fiegler H, Carter NP, Reifenberger G, Korshunov A, Lichter P.
J Clin Oncol 23(34):8853-62. 2005
28CDK6
Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells.
Lim JT, Mansukhani M, Weinstein IB.
Proc Natl Acad Sci U S A 102(14):5156-61. Epub 2005 Mar 24. Erratum in: Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8786-7. 2005
29CDK6, RANBP17, TALL, TLX3
Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia.
Su XY, Busson M, Della Valle V, Ballerini P, Dastugue N, Talmant P, Ferrando AA, Baudry-Bluteau D, Romana S, Berger R, Bernard OA.
Genes Chromosomes Cancer 41(3):243-9. 2004
30CDK6
Translocation t(2;7)(p12;q21-22) with dysregulation of the CDK6 gene mapping to 7q21-22 in a non-Hodgkin's lymphoma with leukemia.
Brito-Babapulle V, Gruszka-Westwood AM, Platt G, Andersen CL, Elnenaei MO, Matutes E, Wotherspoon AC, Weston-Smith SG, Catovsky D.
Haematologica 87(4):357-62. 2002
31CDK14, CDK6, SAMD9, SAMD9L
Human-mouse comparative mapping of the genomic region containing CDK6: localization of an evolutionary breakpoint.
Thomas JW, et al.
Mamm Genome 10(7):764-7. No abstract available 1999
32CDK6
Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations.
Corcoran MM, Mould SJ, Orchard JA, Ibbotson RE, Chapman RM, Boright AP, Platt C, Tsui LC, Scherer SW, Oscier DG.
Oncogene 18(46):6271-7. 1999
33CDK10, CDK9, CDK3, CDK6, CDKN1B
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.
Bullrich F, et al.
Cancer Res 55 : 1199-1205. 1995
34CDK4, CDK6
CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.
Bates S, et al.
Oncogene 9 : 71-79. 1994
35CDK6
Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
Meyerson M, et al.
Mol Cell Biol 14(3):2077-86 1994