Other morbid association(s)
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Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
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tumoral
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results in an increased ability of cells to acquire a transformed phenotype and become malignant, indicating that it is a tumor suppressor  | constitutional
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| loss of function
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promotes aberrant DNA-damage response and genetic instability, leading to defective TP53-mediated signalling and decreased trans-activation of TP53 target genes upon DNA damage  | constitutional
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| loss of function
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may play a role in promoting marrow adiposity under stress or disease conditions, but it is not required for T1-diabetes induced bone loss  | |