| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
|
|
results in an increased ability of cells to acquire a transformed phenotype and become malignant, indicating that it is a tumor suppressor  | | constitutional
|
|
|
| loss of function
| |
promotes aberrant DNA-damage response and genetic instability, leading to defective TP53-mediated signalling and decreased trans-activation of TP53 target genes upon DNA damage | | constitutional
|
|
|
| loss of function
| |
may play a role in promoting marrow adiposity under stress or disease conditions, but it is not required for T1-diabetes induced bone loss | |
